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1

Bacteriophage therapy of bacterial infections: an update of our institute's experience

100%
Weber-Dabrowska B., Mulczyk M., Gorski A.
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vol. 48
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issue 5
547-555
EN
1307 patients with suppurative bacterial infections caused by multidrug resistant bacteria of different species were treated with specific bacteriophages (BP). BP therapy was highly effective; full recovery was noted in 1123 cases (85.9%). In 134 cases (10.9%) transient improvement was observed and only in 50 cases (3.8%) BP treatment was found to be ineffective. The results confirm the high effectiveness of BP therapy in combating bacterial infections which do not respond to treatment with all available antibiotics.
2

Opiate abuse, innate immunity, and bacterial infectious diseases

63%
Wang J., Barke R. A., Ma J., Charboneau R., Roy S.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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vol. 56
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issue 5
299-309
EN
The first line of defense against invading bacteria is provided by the innate immune system. Morphine and other opiates can immediately disrupt the body's first line of defense against harmful external bacteria. Opiate, for example morphine, abuse degrades physical and physiologic barriers, and modulates phagocytic cells (macrophages, neutrophils) and, nonspecific cytotoxic T cells (gd T), natural killer cells, and dendritic cells, that are functionally important for carrying out a rapid immune reaction to invading pathogens. In vitro studies with innate immune cells from experimental animals and humans and in vivo studies with animal models have shown that opiate abuse impairs innate immunity and is responsible for increased susceptibility to bacterial infection. However, to better understand the complex interactions between opiates, innate immunity, and bacterial infection and develop novel approaches to treat and even prevent bacterial infection in the opiate-abuse population, there is an urgent need to fill the numerous gaps in our understanding of the cellular and molecular mechanisms by which opiate abuse increases susceptibility to bacterial infection.
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