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The role of B lymphocytes as antigen-presenting cells

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Chen X., Jensen P. E.

Archivum Immunologiae et Therapiae Experimentalis

2008

vol. 56

issue 2

77-83

B lymphocytes are regarded as professional antigen-presenting cells (APCs) despite their primary role in humoral immunity. Over the last two decades, studies designed to define the role of the B cells as APCs have generated discrepant results, showing that B cells are either unnecessary or required for T cell priming and either immunogenic or tolerogenic to T cells. The reasons for these discrepancies are not clear. Here we review mechanisms regulating B cell antigen presentation and the data derived from the major studies conducted by different groups representing each school of thought. In general it is clear that B cells process and present specific and nonspecific antigens differently. The presentation of specific antigen through the B cell antigen receptor occurs with very high efficiency and is associated with B cell activation, resulting in the activation of cognate T cells. In contrast, the presentation of nonspecific antigen by B cells is minimized and dissociated from B cell activation. As a result, B cells inactivate T cells that recognize nonspecific antigenic epitopes presented by B cells, or they induce regulatory T cell differentiation or expansion. These mechanisms serve to ensure effective production of high-affinity antigen-specific antibodies but minimize the production of nonspecific antibodies and autoantibodies.

Dynamic control of B lymphocyte development in the bursa of Fabricius

100%

Funk P. E., Palmer J. L.

The chicken is a foundational model for immunology research and continues to be a valuable animal for insights into immune function. In particular, the bursa of Fabricius can provide a useful experimental model of the development of B lymphocytes. Furthermore, an understanding of avian immunity has direct practical application since chickens are a vital food source. Recent work has revealed some of the molecular interactions necessary to allow proper repertoire diversification in the bursa while enforcing quality control of the lymphocytes produced, ensuring that functional cells without self-reactive Ig receptors populate the peripheral immune organs. Our laboratory has focused on the function of chB6, a novel molecule capable of inducing rapid apoptosis in bursal B cells. Our recent work on chB6 will be presented and placed in the context of other recent studies of B cell development in the bursa.

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2 Archivum Immunologiae et Therapiae Experimentalis

1 2008

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1 Chen X.

1 Funk P. E.

1 Jensen P. E.

1 Palmer J. L.

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The role of B lymphocytes as antigen-presenting cells

Dynamic control of B lymphocyte development in the bursa of Fabricius