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Synthesis, assessment of substituent effect and antimicrobial activities of some substituted (E)-Nbenzylidene- 5-bromopyridin-2-amines

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Senbagam R., Vanangamudi G., Thirunarayanan G.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2015

vol. 70

issue 2

A series of substituted (E)-N-benzylidene-5-bromopyridin-2-amine compounds have been synthesized from 5-bromo-2-aminopyridine with different substituted benzaldehydes. The structure of the adducts was confirmed by their physical constants, UV, IR and NMR spectral data. The observed UV absorption maximum λmaxC=N(nm), IR frequencies νC=N(cm-1), The 1H and 13C NMR δ(ppm) chemical shifts values have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the spectral data has been studied. The antimicrobial activities of all synthesized imines have been studied using Bauer-Kirby method.

Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones

100%

Vijayakumar R., Senbagam R., Rajarajan M., Balaji S., Manikandan V., Vanangamudi G., Thirunarayanan G.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2015

vol. 70

issue 2

Some novel substituted hydrazone derivatives of amino guanidine have been synthesized with different substituted benzaldehydes by condensation method. The synthesized hydrazones were characterized by their physical constants, UV, IR and NMR spectra. The spectral data have been correlated with Hammett substituent constants and Swain–Lupton parameters. From the result of statistical analysis, the effects of substituents on the spectral data have been predicted. The antimicrobial activities of these synthesized hydrazone compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized hydrazone compounds have shown significant activity.

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2 Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2 2015

2 Senbagam R.

2 Thirunarayanan G.

2 Vanangamudi G.

1 Balaji S.

1 Manikandan V.

1 Rajarajan M.

1 Vijayakumar R.

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Synthesis, assessment of substituent effect and antimicrobial activities of some substituted (E)-Nbenzylidene- 5-bromopyridin-2-amines

Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones