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EVALUATION OF MUTAGENIC PROPERTIES OF 2(C6H15N2O2)+2I3-H2O IODINE COORDINATION COMPLEX IN BACTERIAL REVERSE MUTATION TEST

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Jumagaziyeva A. B., Iskakbayeva Z. A., Myrzabayeva A. N., Suldina N. A., Paretskaya N. A., Datkhaev U. M., Flisyuk E. V., Ilin A. I.

Acta Poloniae Pharmaceutica - Drug Research

2020

vol. 77

issue 3

465-473

Objective: 2(C6H15N2O2)+ 2I3-H2O iodine coordination complex is a new pharmaceutical substance that have high antibacterial activity against both sensitive and multidrug resistant strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa. Methods: Mutagenicity of 2(C6H15N2O2)+2I3-H2O iodine coordination complex was assessed using Salmonella/microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, TA 1537 and Escherichia coli WP2uvrA. The mutagenic activity was determined both in the absence or presence of S9 mixture. Results: The study have shown that test item did not cause any increase in the number of his+ revertants in S.typhimurium and trp+revertants in E.coli WP2uvrA strains in the presence or absence of S9-mix, compared to the controls. Conclusion: Under the conditions of this test and according to the criteria set for the evaluation of the test results, the 2(C6H15N2O2)+ 2I3-H2O iodine coordination complex did not show mutagenic activity in the S. typhimurium and E.coli plate incorporation assay.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 2020

1 Datkhaev U. M.

1 Flisyuk E. V.

1 Ilin A. I.

1 Iskakbayeva Z. A.

1 Jumagaziyeva A. B.

1 Myrzabayeva A. N.

1 Paretskaya N. A.

1 Suldina N. A.

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EVALUATION OF MUTAGENIC PROPERTIES OF 2(C6H15N2O2)+2I3-H2O IODINE COORDINATION COMPLEX IN BACTERIAL REVERSE MUTATION TEST