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THE EEG EXAMINATION, TOGETHER WITH P300 POTENTIAL AS A METHOD FOR CAUSATIVE DIFFERENTIATION IN PATIENTS WITH A GENETIC AND ENVIRONMENTAL CONDITIONING TO ALCOHOL ADDICTION

100%
Chwedorowicz R., Raszewski G., Studziński T.
Acta Neuropsychologica
|
2017
|
vol. 15(4)
457-465
EN
The electrophysiological characteristics of alcoholics, such as the P300 amplitude of the Event-Related Potential (ERP), are related to high risk in their offspring, and are considered to be biological endophenotypes of a predisposition to develop alcohol use disorders. Contemporary knowledge justifies early diagnoses of the alcohol risk degree among adolescents, or even children, including their families, involving an examination of the P300 potential as an endophenotype, prior to achievement of an age of alcohol initiation. The results of such research approaches may be of importance not only cognitively, but also of prophylactically, in the early recognition of increased susceptibility to alcohol. The simplicity and non-invasiveness, and the exceptionally low costs of the methods described, should obtain for the present as well as in the future, a wider examination, one potentially even mass scope of in character and usefulness. The knowledge of such an endophenotype and genetically-related susceptibility, in the individual, family, and social dimension and transmission, and in the rearing of children and adolescents, could protect – not just individuals – but many from entering into the route of addiction, which is most frequently the effect of acting unaware and with negative life consequences, both generational and transgenerational for generations to come.
2
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Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

75%
Jabłonowski Z., Kuydowicz J., Sosnowski M., Różański W., Jabłośki S., Jabłonowska E.
Open Medicine
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2009
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vol. 4
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issue 3
299-303
EN
In the course of cirrhosis, a variety of disturbances of endocrine glands occur. Degenerative changes in the testes with atrophia and fibrosis of the glandular tissue are often found in men. Twenty-one males with compensated alcoholic liver cirrhosis were studied. The age ranged from 29 to 61 years (mean 47,1). Efficiency of the liver was evaluated according to Child classification. HBC (this needs to be spelled out in parenthesis) or HBV (Hepatitis B Virus) infections were excluded. Levels of serum testosterone were determined and the volume size of the testes was measured using 7,5 MHz sector probe, B&K Medical ultrasonograph, 3535 model. Volume size of the testes was measured in 22 healthy control volunteers, as well; age ranged from 25 to 66 years (mean-46,6). All patients were interviewed about sexual function, particularly possible erectile dysfunction using IIEF-5 questionnaire. The mean testosterone level was 8,89 umol/l (ranged: 7,4–10,9 umol/l) in the study patients [the normal range interval: 8,2–34,6 umol/l]. The level was below the normal range in 4 patients, and low but within the normal range in the remaining patients. Statistically significant lower values of both testes volumes were estimated in patients with compensated alcoholic liver cirrhosis in comparison to healthy controls (p<0,001), however only 5 (23,81 %) study group subjects admitted impaired libido and erectile dysfunction. Decreased levels of testosterone in the peripheral blood and diminished volume size of testes are found in patients suffering from alcoholic liver cirrhosis. Erectile dysfunction in patients with liver cirrhosis needs further evaluation.
3
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Risk factors in patients with herpes zoster infections: case-control study

75%
Pezer M., Vidić V., Nikolić J., Curić I., Arapović J.
Open Medicine
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2013
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vol. 8
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issue 4
493-498
EN
The aim of this study was to determine the prevalence of chronic disease and the risk factors for herpes zoster infection. In this case-control study medical records were collected from 55 patients who presented with herpes zoster and 54 patients in a control group who presented with gastroenterocolitis. Both groups were treated at the Clinic for Infectious Diseases, University Clinical Hospital Mostar from January, 2005 to December, 2010. When we compared the herpes zoster group with the control group, we did not demonstrate any significant difference in the overall prevalence of chronic diseases. However, the prevalence of diabetes and cancer was statistically higher when compared to the control group. A statistically significant difference in the number of cigarette smokers was not observed, whereas the number who consumed alcohol in the herpes zoster group was significantly higher compared to the control group. The correlation between alcohol and herpes zoster could help in solving the reactivation mechanism of VZV.
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