Search results

Search:
in the keywords: ARTERIAL BLOOD PRESSURE

Sort By:

Limit search:

Dual response of cerebrocortical blood flow and arterial blood pressure to transient CO2 stimulus after inhibition of nitric oxide synthesis in rats

100%

Wolk R., Sieminska J., Trzebski A.

Acta Neurobiologiae Experimentalis

1995

vol. 55

issue 2

73-83

Inhibition of nitric oxide synthase (NOS) by Nitro-L-arginine-methyl-ester in 16 male Wistar rats anaesthetized with urethane, paralysed and artificially ventilated, increased siginficantly local peripheral vascular resistance in the parietal cortex (CVR) along with augmentatoin of the mean arterial blood presure (MP) and no change of the local cerebrocortical blood flow (CBF) recorded with a Laser-Doppler-Flowmeter.In 11 rats L-NAME reversed a pressor effect of brief hypercapnia induced by 10% Co2/air mixture into depressor esponse,reduced CBF esponse proportionally to the reduction of MAP and did notinfluence CVR response to CO2. In 5 rats L-NAME did not abolish the central pressor effect of CO2-stimulus and significantly augmented CO2-induced vasodilatory response in the cortex by a larger reduction of CVR.It is concluded that NO does not mediate the vasodilatory effect of brief hypercapnia in the cortex.NO apears critical for the central pressor effect of CO2.In those rats in which the central pressor effect of a CO2-stimulus was not abolished by an NOS blocker, an increased CBF and augmented decrease in CVR was observed during brief hypercapnia.Possible mechanisms of this dual responsiveness of cortical blood flow and arterial blood pressure to CO2, induceds bu inhibition of NOS, are discussed.

Effect of increased intracranial pressure on arterial peripheral and cerebral blood pressure

88%

Dmowska M., Schoenborn R., Modrzejewski E.

Folia Biologica

1996

vol. 44

117-122

The effect of increased intracranial pressure (ICP) on arterial peripheral (PBP) and cerebral blood pressure (CBP) was studied in 16 rabbits (New Zealand White). Changes of arterial blood pressure in peripheral and cerebral blood circulation were caused by a temporary (3 min) ICP increase. A raised ICP was obtained by infusing into the left lateral brain ventricle artificial cerebrospinal fluid at a pressure equal to 50, 100, and 150% of the initial CBP value. The experiments carried out showed that on reaching the initial CBP value, increased ICP induced Cushing response. The magnitude and duration of this reaction changed with increasing ICP, the intensity of the changes depending on the brain region in which the ICP increase was initiated.

Refine search results

1 Acta Neurobiologiae Experimentalis

1 Folia Biologica

1 1996

1 1995

1 Dmowska M.

1 Modrzejewski E.

1 Schoenborn R.

1 Sieminska J.

1 Trzebski A.

1 Wolk R.

Search results

Dual response of cerebrocortical blood flow and arterial blood pressure to transient CO2 stimulus after inhibition of nitric oxide synthesis in rats

Effect of increased intracranial pressure on arterial peripheral and cerebral blood pressure