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Some factors affecting the unique thermotolerance of hyperthermophiles

100%

Grzybowska B., Synowiecki J.

Biotechnologia

2003

issue 2

192-205

The unique thermotolerance of hyperthermophiles, suitable as valuable sources of thermostable enzymes, is a result of various minor changes which led to the restriction of protein flexibility and modifications of nucleic acids and membrane lipids. Furthermore, all hyperthermophiles produce a number of heat shock proteins and thermoprotectants. Thermal resistance of these microorganisms is also enhanced by rapid resynthesis of thermolabile compounds and by elimination of such intermediates from cell metabolism.

New insights into phylogeny from genomic point of view

88%

Sobczynski M., Mackiewicz P., Mackiewicz D., Smolarczyk K., Cebrat S.

Biotechnologia

2005

issue 3

102-117

Availability of fully sequenced genomes contributes to the development of new science named phylogenomics which opens new possibilities of phylogenetic analyses and study of genome evolution based on the whole information coded in genomic DNA. The advantages and disadvantages of the new methods are described. Despite many phenomena such as lineage-specific gene loss, gene duplication and horizontal gene transfer disturbing phylogenetic analyses, the new methods are able to extract some phylogenetic signals in the analysed genomes and construct reliable phylogenetic trees. The genome-based studies support not only the three-domain concept of Tree of Life but they identify previously undetected major clades of prokaryotes as well.

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2 Biotechnologia

1 2005

1 2003

1 Cebrat S.

1 Grzybowska B.

1 Mackiewicz D.

1 Mackiewicz P.

1 Smolarczyk K.

1 Sobczynski M.

1 Synowiecki J.

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Some factors affecting the unique thermotolerance of hyperthermophiles

New insights into phylogeny from genomic point of view