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1

Discriminative stimulus properties of /+/-oxaprotiline in rat

100%
Filip M., Chojnacka-Wojcik E., Przegalinski E.
|
EN
Using a drug discrimination procedure on a fixed ratio (FR) 10 schedule of reinforcement, rats were trained to distinguish between the stimulus properties of the selective inhibitor of noradrenaline uptake (+)-oxaprotiline ((+)-OXA) and saline. Fifty per cent of the rats that learned to reliably discriminate (+)-OXA from saline, reached high discrimination accuracy. In substitution testing, maprotiline (MAP) and desipramine (DMI) produced dose-related responding on the (+)-OXA lever. (-)-OXA failed to show substitution. The results of our findings demonstrate that (+)-OXA may be used as a discriminative cue in rats. The NA uptake inhibition seems to be involved in the effect of this drug.
2

Electrophysiological studies on the effects of antidepressant drugs and corticosterone on serotonin receptors in the hippocampus

80%
Zahorodna A., Tokarski K., Bijak M.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
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issue 3
391-401
EN
Disturbances in the serotonin (5-HT) system and the limbic-hypothalamo-pituitary-adrenal axis (LHPA) have been implicated in the pathophysiology of depression. It is well established that hippocampus is a central component of limbic circuitry that participates in the modulation of cognition, mood and behavior, and is involved in the control of the LHPA axis. Therefore, the hippocampus provides a unique environment to study the interplay between serotonergic system, antidepressants and corticosteroids. Activity of hippocampal cells can be modulated by 5-HT via inhibitory 5-HT1A and excitatory 5-HT4 receptors. Repeated treatment with antidepressants increases the responsiveness of hippocampal pyramidal neurons to the 5-HT1A and attenuates the responsiveness to the 5-HT4 receptor agonists, with a time course which correlates with the delayed onsed of the therapeutic effect of antidepressants in humans. Moreover, repeated corticosterone, which may constitute a model of a prolonged nonadaptable stress, has opposite effect on hippocampal responsiveness to the 5-HT1A and 5-HT4 receptor activation. Such an action results in an enhancement of the 5-HT-mediated inhibition by antidepressants and a reduction in the inhibitory effect of 5-HT by corticosterone which may be relevant to antidepressant/antiaxiety and proaxiety effects, respectively, of both treatments.
3

The action of antidepressant drugs administered during calcium channel blockade

61%
Vetulani J.
Polish Journal of Pharmacology
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1993
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vol. 45
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issue 2
179-184
EN
This is an overview of the symposium concerned with the action of electroconvulsive treatment and some antidepressant drugs (mainly imipramine) applied during blockade of voltage-dependent calcium channels with nifedipine. The results in general suggest that a combination of calcium channel blockers with antidepressant drugs of ECT may be of clinical value in treatment of depression.
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