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1

Angiotensin II receptor antagonists

100%
Karasek D., Adamski M., Grzeszczak W.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
|
vol. 50
|
issue 1
21-32
EN
Angiotensin II exerts its activity by binding to its receptors. The two main types AII receptors, properties of Losartan (first orally active, specific, competetive, nonpeptide AII receptor antagonist) and its clinical applications are described.
2

Renin-angiotensin system and atherosclerosis

80%
Stajszczak M., Gminski J.
Postępy Higieny i Medycyny Doświadczalnej
|
1993
|
vol. 47
|
issue 6
475-485
3

Psychotropic effects of angiotensin II N-terminal fragments in rats

70%
Holy Z., Braszko J., Wisniewski K.
Polish Journal of Pharmacology
|
1993
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vol. 45
|
issue 1
31-41
EN
In this study the effects of angiotensin (AII) angiotensin II hexapeptide [AII(1-6)] and angiotensin II pentapeptide [AII(2-6)] on the motility, stereotypy, learning of conditioned avoidance responses (CARs) and recall of a passive behavior making it possible to avoid averisve stimulation in rats, were compared. All the peptides were injected into the lateral cerebral ventrice (icv) in a dose of 1nmol. AII caused a statistically significant increase in the number of crossings, rearings, and bar approaches in an open field whereas [AII(1-6)] and [AII(2-6)] were inactive in this test. The stereotypic behavior induced by an intraperitoneal (ip) injection of apomorphine (1mg/kg) and amphetamine (7,5 mg/kg) was statistically significantly enhanced only in the rats wihich received AII icv. The application of AII, but not that of [AII(1-6)] and [AII(2-6)] resulted in a quicker acquisition of the CARs. A better recall of passive avoidance was achieved only by AII, while the fragments [AII(1-6)] and [AII(2-6)] had no effect. These findings indicate that the 1-6 and 2-6 fragments of AII do not possess a psychotropic activity like that of the parent ictapeptide.
4
Content available remote

CGP 42112A abolishes facilitation of recognition caused by angiotensin II and angiotensin II(3-7) in rats

70%
Braszko J. J., Kulakowska A., Winnicka M. M., Karwowska-Polecka W.
Acta Neurobiologiae Experimentalis
|
1997
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vol. 57
|
issue 3
227-234
EN
The role of the angiotensin AT2 receptors in some behavioural effects of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole each, substantially improved object recognition memory and enhanced apomorphine (1 mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A per se ineffective in all tests, abolished activity of both peptides. None of the treatments significantly changed behaviour of rats in open field. The results point to the considerable involvement of the AT2 angiotensin receptors in the improvement of recognition memory caused by Ang II and Ang II(3-7).
5

The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

61%
Wisniewski K., Borawska M., Car H.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 1
23-29
EN
Angiotensin II (1-8) (A II) and its fragments: angiotensin III (2-8) (A III), angiotensin IV (3-8) (A IV), angiotensin V (4-8) (A V) and angiotensin VI (3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.
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