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  1. 1 Polish Journal of Pharmacology

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  1. 1 1993

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  1. 1 Malec D.

  2. 1 Michalska E.

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Agonists and antagonists of adenosine receptors and morphine withdrawal syndrome in rats

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Michalska E., Malec D.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 1
1-9
EN
The compounds activating adenosine system alleviated morphine withdrawal syndrome (the number of escape attempts and body shakes) in rats. Body shakes were decreased mostly by N-ethylcarboxamidoadenosine, cyclohexyladenosine, dipyridamole and 2-chloroadenosine, while R-phenylisopropyladenosine very strongly decreased the number of escape attempts. Adenosine receptor antagonists (caffeine and theophylline) increased the number of escape attempts in morphine-dependent rats. Caffeine (10 mg/kg), administered preventively, antagonized the ingibitory effects of adenosine analogs. These results suggest the existence of relation between opioid receptors and the adenosine system.
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