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1

The presence of acetylcholinesterase-positive nerve fibers in the deep pineal gland and the pineal stalk but not in the superficial part of adult albino rats

100%
Swiatkiewicz G.
Folia Biologica
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2000
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vol. 48
|
issue 3-4
97-103
EN
Application of the histochemical method for testing acetylcholinesterase (AChE, EC 3.1.1.7) showed the presence of AChE-positive nerve fibers in the deep pineal gland and the pineal stalk but not in the superficial part of adult albino rats. These findings may indirectly support the existence of the potentially cholinergic innervation of at least some of the rat pinealocytes present in these parts of the gland and augment the evidence of the heterogeneity of the rat pinealocytes. It is possible that cholinergic neurons in the medial habenular nuclei or in the parasympathetic sphenopalatine ganglion may be a source of these AChE-positive fibres.The examination was performed at the light microscope level.
2

Kinetics of organophosphorus pesticide inhibition of acetylcholinesterase (E.C.3.1.1.7) from the head of Tryporyza nivella (Fabr.) (Lepidoptera:Pyralidae)

100%
Pandey G.
Folia Biologica
|
1995
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vol. 43
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issue 3-4
161-167
EN
Kinetic constans(Kd, k2 and ki values) for the inhibition of the Tryporyza nivella head acetylcholinesterase (ChE)by organophosphorus (Trichlorfon, Malaoxon and Diazoxon) pesticides were determined in vitro.These compounds showed a high affinity for AChE and the affinity constans (Kd).There was a little variation among the phosphorylation constans (K2), indicating a minor role for the phosphorylation step in the inhibition process.The significant variation of the molecular reaction (ki) of these compounds could be attributed to variation in the Kd rather than to the K2.Trichlorfon, having a higher ki value, was found to be less toxic than Malaoxan and Diazoxon.
3
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Effect of the cholinesterase-inhibiting substance galanthamine on evoked visual potentials in rats

88%
Lewandowski M. H., Zmuda L.
Acta Neurobiologiae Experimentalis
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1995
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vol. 55
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issue 2
141-145
EN
We studied the effect of intravenous injection of the cholinesterase inhibitor galanthamine (GAL) in doses from 0.025 to 5.0 mg/kg on electrically evoked field potentials in rat visual cortex.In all the experiments the amplitude of late components of evoked potentials was significantly reduced, while early components remained unaffected.These findings indicate that cortical cells are inhibited by acetylocholine (ACh).Furthermore, combined application of a muscarinic receptor blocker (atropine) and GAL reliably suppressed the effects of galanthamine.These observations suggest that ACh-induced inhibition may be mediated by activation of GABAergic interneurones that possess muscarinc receptors.
4

A morphologixal study of the testes in relation to acetylcholinesterase actvity in the brain and testis of an organophosphate pesticide ingested by a wild passerine bird (Lonchura malabarica)

88%
Maitra S., Sarkar R.
Folia Biologica
|
1995
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vol. 43
|
issue 3-4
143-149
EN
Oral administration of an organophosphate pesticide, phosphamidon, at sublethal doses caused a decrease in both and testicular acetylcholinesterase (AChE), paired testicular weight, seminiferous tubular diameter, and the number of tubules containing healthy germ cells in the testes of adult whitetroated munias in a dose and duration depended manner.While no significant changes in the cytomorphology and nuclear diameter of Leyding cells were noted in the testes of the experimental birds, a significant negative correlation was observed between the number of semiferous tubules containing degenerated germ cells and the rate of AChE activity in both the testes and in the brain of respective bird groups.These findings demonstrate for the first time that the antigametogenic effects of an OP pesticide on avian tests may be due to impaired cholinergic functions in the brain and/or the testes in the birds concerned.
5
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Effects of early undernutrition on kinetic parameters of brain acetylcholinesterase from adult rats

88%
Rocha J. B. T., Emanuelli T., Pereira M. E.
Acta Neurobiologiae Experimentalis
|
1993
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vol. 53
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issue 3
431-437
EN
The effects of during early life on acetylcholinesterase (AChE) specific activity of , and were examined in rehabilitated adults . Undernourished rats were raised by dams maintained on a scheme from pup birth to pup weaning. The offspring were maintained on a restricted food schedule until day 38 when they started to have free access to food until 70-80 days of age. Control rats were raised by dams which had free access tofood. The results showed that early malnutrition caused a significant increase in AChE specific activity in cerebellum (about 20%), striatum (about 40%), and hypothalamus (about 30%). No changes were found in the hippocampus. Undernutrition caused a significant increase in Vmax when compared to the control group without changes in Km both in cerebellum and striatum. These results suggest that early undernutrition changes AChE concentration in cerebellum and striatum and does not affect the affinity of the enzyme for the substrate.
6

Effects of phenylhydrazine or recombinant human erythropoietin on deformability and activity of dehydrogenase glucose-6-phosphate and acetylcholinesterase in Wistar rats blood enriched in reticulocytes

75%
Nowak E., Wyrwicz G., Dabrowski Z., Smolenski O., Spodaryk K.
Folia Biologica
|
2003
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vol. 51
|
issue 3-4
195-199
EN
Deformability and activity of the enzymes: acetylcholinesterase (AChE) and dehydrogenase glucose-6-phosphate (G-6-PD), were assayed for RBC enriched in immature reticulocytes. Reticulocytosis was evoked by administration of two different drugs: recombinant human erythropoietin (rHuEPO) and phenylhydrazine (PHZ) to two groups of Wistar rats. After treatment with the former compound, a group of animals exhibited 17,33 % reticulocytes in blood whereas a group of rats treated with the latter drug reached 57,66 % of these cells in blood. A marked decrease in RBC deformability was found in both groups of animals. AChE did not significantly change activity neither in PHZ-treated nor in rHuEPO-treated rats, whereas G-6-PD activity was significantly decreased in the PHZ-treated group.
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