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Study of the Anti-Inflammatory Activity of Flavonic Extract of Globularia alypum L.

100%
Boutemak K., Safta B., Ayachi N.
Acta Physica Polonica A
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2015
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vol. 128
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issue 2B
B-239-B-240
EN
Globularia alypum L. of the family Globulariaceae is widely used in traditional medicine for its anti-inflammatory activity. The aim of this study is to evaluate the anti-inflammatory activity of flavonic extract (butanol fraction) of globularia alypum against carrageenan induced paw-oedema in mice. The results have shown that the dose of 0.3 g/ml of butanol fraction present the most significant activity (33.01%) compared with reference product aspirine (39.76%) at dose of 2 mg/ml.
2
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Modelling of Stimulation Environment Using Monophasic Rectangle Pulse for Various Stimulation Parameters

63%
Celik M., Karagoz I.
Acta Physica Polonica A
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2015
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vol. 128
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issue 2B
B-297-B-299
EN
Recently, both the progress in some technological fields and multidisciplinary studies conducted with collaboration from different branches of science have impressive effect on clinically tested systems. Studies on development of visual prosthesis, which is based on passing damaged parts of the visual pathway and electrically stimulating nerve cells remaining intact, date back to elicit visual sense in blind patients. Investigation of some research topics, in silico, which should be taken into consideration in the design phase before expensive animal experiments provides great advantages in terms of both financial and time issues. In this study, factors such as heat, electric field distribution for current thresholds, current density which should be discussed in the design phase are simulated using monophasic rectangle pulses depending on various stimulation parameters with developed computational retina model. Change of heat, electric field, current density in points selected from center and periphery of retina tissue are investigated for various stimulation parameters. As a result, it is concluded that distribution of heat and electric field intensity over the periphery retina are much less than center region. Moreover, when larger pulse width is used, change of heat and electric field intensity seems much more in regions from center retina near stimulation electrode. Current density is higher in the sharp ends of the electrode than flat regions. Besides, when the size of stimulation electrode increases, electric field distribution becomes more uniform.
3
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Dependence of Ultrasonic and Magnetic Hyperthermia on the Concentration of Magnetic Nanoparticles

51%
Kaczmarek K., Hornowski T., Bielas R., Żak D., Timko M., Józefczak A.
Acta Physica Polonica A
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2018
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vol. 133
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issue 3
716-718
EN
Hyperthermia treatment is the heating of tumor tissue up to temperatures between 41°C and 45°C, which trigger several physiological reactions in the body. Hyperthermia within tissue can be applied through various mechanisms. One of them is magnetic hyperthermia which uses superparamagnetic iron oxide nanoparticles (SPIONs) heated by an externally applied magnetic field. SPIONs can also be used as sonosensitizers in ultrasound hyperthermia increasing acoustic wave attenuation. The impact of SPION concentration on thermal effect during ultrasonic and magnetic hyperthermia was investigated in agar-gel phantom with added magnetite nanoparticles. The presence of nanoparticles in the tissue-mimicking phantom increases the thermal losses of ultrasound energy and temperature of the phantom.
4
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Magnetic Polymer Nanocomposite for Medical Application

38%
Świętek M., Tokarz W., Tarasiuk J., Wroński S., Błażewicz M.
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vol. 125
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issue 4
891-894
EN
Magnetic sponges derived from biocompatible and resorbable polymers are promising materials for medical applications. These materials have been utilised extensively in research applications for the capture of biomolecules and cells, the construction of tissue scaffolds and in regenerative medicine. The object of this study was a polymer scaffold made of polycaprolactone (PCL) containing a 10 wt% amount of nanomagnetite, manufactured in a two-step method. The porosity and morphological parameters were characterised with the use of μ-computer-aided tomography and scanning electron microscopy. Furthermore, the magnetic properties were evaluated. The obtained results confirmed high porosity and the appearance of randomly oriented pores. Moreover, evaluations of the magnetic properties, of both the magnetite nanopowder and the prepared magnetic nanocomposite, were performed. The tests verified the ferromagnetic character of the materials under investigation.
5
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Rabbit Retinal Ganglion Cell Activation Thresholds in Response to Various Electrical Stimulation Waveforms using a Different Spatial Resolution Electrode Array

38%
Çelik M., Özden M., Karagöz İ., Sobaci G.
Acta Physica Polonica A
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2017
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vol. 131
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issue 6
1479-1484
EN
The analysis of retinal ganglion cell responses to electrical stimulation is invaluable way to understand how the retina reacts and develops. Artificial visual prosthetics have made progress to some extent. Although there are several studies about retinal ganglion cell responses in the literature, experimental findings and information about responses to special stimulation patterns for developing high-resolution visual prosthetics are quite limited. In this study, rabbit retinal tissue was stimulated by biphasic, monophasic and ramp function current pulses with various amplitudes and pulse widths in a set of in vitro experiments. Rabbit retinal ganglion cell responses and spike activities are comparatively analyzed based on the applied electrical stimulation parameters. We conclude that biphasic current pulses provide a lower stimulation threshold of 10 μA with shorter pulse widths than those obtained by monophasic stimulation. Additionally, despite the fact that ramp function stimulation patterns have remarkable potential for eliciting spike formation with low stimulation thresholds, biphasic stimulation is charge-balanced and more convenient for high-resolution visual prosthesis systems.
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