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EN
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. In this study, nanocomposite scaffolds composed of polycaprolactone and multi-walled carbon nanotubes, containing different amounts of carbon nanotubes, were prepared via solvent casting and vacuum drying technique, for myocardial tissue engineering. Characterization techniques such as Fourier transform infrared spectroscopy and scanning electron microscopy were used. Furthermore, mechanical properties of the prepared polycaprolactone and nanocomposite scaffolds were determined. The results have revealed that the scaffolds contain sufficient porosity with highly interconnected pore morphology. Addition of carbon nanotubes to the polycaprolactone matrix has improved conductivity of the prepared scaffold. The desired distribution of carbon nanotubes with a few agglomerates was observed in the nanocomposite scaffolds by scanning electron microscopy. Polycaprolactone/multi-walled carbon nanotubes nanocomposite scaffold containing 1 wt% of carbon nanotubes has shown the best mechanical behavior and electrical conductivity. In conclusion, the electrically conductive and nanofibrous polycaprolactone/1 wt% multi-wall carbon nanotubes scaffold could be used as an appropriate construct for myocardium regeneration and it deserves further investigations.
EN
The surface of NiTi shape memory alloys applied as long-term implants has been modified by protective calcium phosphates (CaPs) coatings, with the objective of improving the biocompatibility of this material. The calcium phosphates such as hydroxyapatite Ca₅(PO₃)OH (HAP) and β-tricalcium phosphate β-Ca₃(PO₄)₂ (β-TCP) were deposited by electrophoretic deposition. In order to improve the adhesion, the deposited samples were vacuum-sintered at wide range of temperature from 500°C to 1000°C for 2 h. The studies revealed that applied sintering conditions did not change the structure of CaPs. The coatings consisted of HAP with hexagonal structure (P63/m) and β-TCP with rhombohedral structure (R-3c). Changes in lattice parameters for CaPs coatings after deposition and sintering were refined by the Rietveld method.
EN
In this study several bioceramic materials (i.e. hydroxyapatite, whitlockite) were prepared by using chemical synthesis method from sea snail shells (Tiger Cowrie - Cypraea Tigris), originated from Pacific Ocean. Marine shells usually present aragonite-calcite structures and generally, complicated and pressurized equipment is necessary to convert these structures into bioceramics. Instead of using complicated systems, a basic ultrasonic equipment and simple chemical synthesis method was used in the process. DTA analysis was performed to calculate the required amount of H₃PO₄ solution in order to set the appropriate stoichiometric ratio of Ca/P equal to 1.667 for HA bioceramic or to 1.5 for β-TCP bioceramic in the titration. The prepared batches were sintered at 800°C and 400°C for hydroxyapatite (HA) and β-tri calcium phosphate (β-TCP) forms respectively. X-ray diffraction analysis, scanning electron microscopy (SEM) and infrared observations (FTIR) were implemented for both TCP and HA bioceramics. By applying the chemical synthesis with basic ultrasonic equipment, this study proposes a simple way of production for nano-HA /TCP powders from a natural marine sources.
EN
The surface of NiTi shape memory was modified by deposition of chitosan-ZnO thin film. The electrodeposition process was carried out at room temperature at voltage-time conditions: 10 V/30 s, 10 V/300 s, 20 V/30 s, or 20 V/300 s. Structure of the obtained coatings was studied by means of grazing incidence beam X-ray diffraction. Distribution of the zinc oxide particles in the chitosan matrix was observed with use of scanning electron microscopy. It was found that depending on the electrodeposition parameters, the structure of the obtained chitosan-ZnO coatings varies from amorphous to coarse-grained.
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