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Chemical Composition of Atherosclerotic Plaques οf apoE/LDLR-Double Knockout Mice by Synchrotron Radiation FTIR Microspectroscopy

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Kowalska J., Gajda M., Kwiatek W., Franczyk-Żarów M., Kostogrys R., Chłopicki S., Sandt C., Dumas P.

Acta Physica Polonica A

2012

vol. 121

issue 2

555-560

Atherosclerosis is a multietiological inflammatory disease of large and medium-sized arteries of increasing incidence in westernized countries. The aim of this study was to identify the biochemical changes during the progression of atherosclerosis by synchrotron radiation Fourier transform infrared microspectroscopy in atheromas of apoE/LDLR^{-/-} mice fed egg-rich diet supplemented or not with angiotensin converting enzyme inhibitor perindopril. Synchrotron radiation Fourier transform infrared microspectroscopy technique was used to obtain information at high spatial resolution about the distribution of proteins (C-N, N-H, CO for amide I and amide II bands), lipids (CH_2, CH_3 bands) as well as mineral deposits (calcium carbonates and phosphates). Total contents of lipids and proteins were found to be significantly lower in animals treated with the diet and perindopril. An increase in saturation level of lipids was observed in animals fed with egg-rich diet when compared to the normal diet and perindopril treatment, which did not inhibit this effect. Moreover, a significant change in the secondary structure of proteins (ratio between absorption bands 1634 cm^{-1}/1656 cm^{-1} attributed to β-type and α-type, respectively) was observed in both experimental groups in comparison with the control. Principal component analysis was used to analyse the recorded spectra. It has revealed that higher content of phosphates (wavenumber range 950-1020 cm^{-1}) was observed between egg-rich diet fed animals and the control group.

Comparison of Iron Oxide-Related MRI Artifacts in Healthy and Neuropathological Human Brain Tissue

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Masarova M., Krafcik A., Teplan M., Strbak O., Gogola D., Boruta P., Dobrota D., Frollo I.

Acta Physica Polonica A

2017

vol. 131

issue 4

1108-1110

The aim of this study is to clarify whether clinical magnetic resonance imaging data can be utilised to evaluate the pathological processes associated with disrupted iron homeostasis, such as neurodegenerative processes or cirrhosis. Although MRI has the potential to become a non-invasive biomarker of such pathology, new quantification methods must be introduced. Our findings confirmed that it is possible to detect significant difference between healthy and pathological tissue from standard T2 weighted MRI protocols.

Characterization of Fe_3O_4 Magnetic Nanoparticles Modified with Dextran and Investigation of Their Interaction with Protein Amyloid Aggregates

100%

Koneracká M., Antošová A., Závišová V., Lancz G., Gažová Z., Šipošová K., Juríková A., Csach K., Kováč J., Tomašovičová N., Fabián M., Kopčanský P.

issue 5

983-985

Functionalised magnetic nanoparticles composed of Fe_3O_4 particles stabilised by sodium oleate and subsequently modified with dextran (MFDEX) were prepared by the co-precipitation method. Their morphology and particle size distribution were observed by scanning electron microscopy and photon cross correlation spectroscopy. In order to confirm the modification of magnetite surface with dextran physical techniques, including infrared spectroscopy, thermal analysis, and magnetic measurement, were used. Finally, the effect of MFDEX on amyloid fibrillar aggregates of human insulin and hen egg white lysozyme, typical amyloidogenic proteins, was investigated. In vitro interaction of MFDEX with protein amyloid fibrils resulted into destruction of amyloid aggregates. The anti-amyloid activity makes MFDEX of potential interest as therapeutic agent against amyloid-related diseases.

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3 Acta Physica Polonica A

1 2017

1 2012

1 2010

1 Antošová A.

1 Boruta P.

1 Chłopicki S.

1 Csach K.

1 Dobrota D.

1 Dumas P.

1 Fabián M.

1 Franczyk-Żarów M.

1 Frollo I.

1 Gajda M.

1 Gažová Z.

1 Gogola D.

1 Juríková A.

1 Koneracká M.

1 Kopčanský P.

1 Kostogrys R.

1 Kováč J.

1 Kowalska J.

1 Krafcik A.

1 Kwiatek W.

1 Lancz G.

1 Masarova M.

1 Sandt C.

1 Strbak O.

1 Teplan M.

1 Tomašovičová N.

1 Závišová V.

1 Šipošová K.

Search results

Chemical Composition of Atherosclerotic Plaques οf apoE/LDLR-Double Knockout Mice by Synchrotron Radiation FTIR Microspectroscopy

Comparison of Iron Oxide-Related MRI Artifacts in Healthy and Neuropathological Human Brain Tissue

Characterization of Fe_3O_4 Magnetic Nanoparticles Modified with Dextran and Investigation of Their Interaction with Protein Amyloid Aggregates