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Ekspresja P-selektyny na powierzchni płytek krwi indukowana endotoksyną bakteryjną Proteus mirabilis

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Saluk-Juszczak J., Nowak P., Golański J., Wachowicz B., Kaca W., Uniwersytet Łódzki K. B. O., Akademia Medyczna w Łodzi I. K.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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2001
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vol. 15
EN
P-selectin is stored in the a granules of blood platelets. Following platelet activation by different agonists, P-selectin is expressed on the cell surface where it mediates adhesion primarily to leucocytes.The aim of the study was to evaluate the direct effect of Proteus mirabilis lipopolysaccharides on the P-selectin expression on the platelet surface measured by cytometric method. The obtained results showed that LPS in vitro induced the expression of P-selectin (CD62) on platelets. It indicates that endotoxin from Gram-negative bacteria can activate blood platelets.
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