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1
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Proces sekrecji płytek krwi wywołany promieniowaniem UVB

100%
Bednarska K., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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2001
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vol. 15
EN
The effects of two doses of UVB radiation (1.08 J/cm2 and 4.32 J/cm2; 1.2 mW/cm2) on blood platelets secretion of adenine nucleotides and proteins and P selectin expression were studied. The effect of UVB radiation on P selectin expression (marker of platelet activation) was compared with the effect of thrombin, which is a strong platelet agonist. The obtained results showed that exposure of blood platelet to UVB radiation caused the release of adenine nucleotides, but proteins in a small amount. Moreover, UVB radiation caused decrease of P selectin expression on blood platelets, in opposite to the effect of thrombin. It seems that UVB radiation can partly activate blood platelets, but the mechanism is needed to be explain.
2
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Zastosowanie lateksu w medycynie i biologii

100%
Nowak P., Pluskota E., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
3
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Peroksydacja lipidów płytek krwi świni stymulowana działaniem cis- i transplatyn

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Wachowicz B., Olas B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1996
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vol. 11
EN
The effects of cisplatin (cisdiamminedichloroplatinum II) at the concentration of 20 µM and transplatin (transdiamminedichloroplatinum II) at the concentrations of 20 µM and 200 and transplatin at the concentration of 200 µM were found to cause a significant increase of thiobarbituric add reactive substances (TBARS). We have demonstrated, that cisplatin - induced platelet lipid peroxidation was enhanced by hypertermia and the presence of plasma had no protective effect on dsplatin or transplatin - stimulated TBARS generation in pig blood platelets. The extracellular GSH (1 mM) protects against dsplatin - induced lipid peroxidation in blood platelets measured as TBARS.
4
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Selen w organizmach żywycch II. Selenobiałka ssaków

100%
Żbikowska H., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
5
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Wstęp

100%
Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
6
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Wpływ seleninu sodowego na białka płytek krwi świni

100%
Żbikowska H., Krajewski T., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1996
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vol. 11
7
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Selen w organizmach żywych. I. Toksyczność selenu i działanie antynowotworowe

100%
Żbikowska H., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1997
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vol. 12
EN
Selenium is an essential trace element supplied to the organism in a relatively narrow range of concentration. Metabolism of inorganic and organic selenium compounds in animals, their role in selenium toxicity and selenium carcinostatic activity are presented.
8
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Aktywność wybranych enzymow krwi w obecności Rożnych stężeń jonow kadmu, miedzi, cynku i seleninu

100%
Zgirski A., Hilewicz-Grabska M., Krajewski T., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
9
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Wpływ związków platyny na generowanie anionorodnika ponadtlenkowego w płytkach krwi świni

100%
Olas B., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1996
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vol. 11
10
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Zmiany poziomu glutationu i aktywności transferazy glutationowej w płytkach krwi indukowane związkami selenu

100%
Żbikowska H., Krajewski T., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1997
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vol. 12
EN
The effects of inorganic selenocompounds (sodium selenite and selenate) on the level of reduced glutathione, free sulfhydryl groups of proteins and the activity of S-glutathione transferase (GST) in pig blood platelets were studied. It was shown that selenite, contrary to selenate reduced the amounts of both GSH and -SH of platelet proteins. The concentration of GSH after one-hour treatment of platelets with a high dose of selenite (10-4 M) was reduced by 50%. A decrease in protein thiols was also significant. We observed that the activity of platelet GST was inhibited after incubation of these cells with a toxic dose of selenite but not selenate.
11
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Zmiany aktywacji płytek krwi wywołane działaniem leku antynowotworowego - cisplatyny

100%
Olas B., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1997
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vol. 12
EN
The effects of cisplatin and transplatin on the ADP (10 μM) - induced aggregation and secretion in vitro were studied. Platinum compounds had an inhibitory effect on ADP-induced platelet aggregation and secretion of adenine nucleotides and proteins from blood platelets. Cisplatin and transplatin also changed the metabolism of endogenous platelet arachidonate and thromboxne A2 synthesis in platelets stimulated by thrombin.
12
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Receptory purynowe na płytkach krwi

100%
Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
13
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Wpływ izomerów platyny na białka cytoszkieletu płytek krwi świni

100%
Olas B., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1997
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vol. 12
EN
The effects of cisplatin (cis-diamminedichloroplatinum II, CDDP) and transplatin (transdiamminedichloroplatinum, TDDP) at concentrations o f 0.1, 1 and 10 /¿M on platelet cytoskeleton protein composition were studied in vitro. Cisplatin and transplatin were found to cause the changes of cytoskeleton proteins. On the other hand in the presence of CDDP (20 μM) the percent of G-actin was reduced.
14
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Znaczenie erytrocytów w aktywacji płytek krwi

100%
Olas B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
EN
The blood platelet activation plays an important role in haemostasis. Mechanism of platelet activation is accompanied by intracellular signal transduction pathways that are responsible for different physiological responses of platelets: changes in platelet shape, release of their granule contents and platelet aggregation. Platelets circulate in vivo together with huge masses of erythrocytes and some leukocytes. Cell-cell interactions between platelets and neutrophils or platelets and erythrocytes can significantly alter platelet reactivity. In recent years demonstrated that erythrocytes may enhance platelet release reaction and eicosanoid synthesis. Role of erythrocytes in blood platelet activation are described and eicosanoid synthesis.
15
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Aktywność biologiczna lipopolisacharydu bakteryjnego

100%
Saluk-Juszczak J., Wachowicz B., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
EN
The purpose of this paper is to briefly review the structure and biological activity of bacterial endotoxin. Endotoxin or lipopolisaccharide (LPS) is the major component of the ou ter membranes of the cell walls of Gramm-negative bacteria. LPS consists of two parts: the hydrophobic lipid A and hydrophylic polysaccharide with contrasting chemical and physical properties. The toxic activity is principally due to its lipid A moiety. LPS is capable of inducing stimulation of immunological system acting on monocytes, macrophages, granulocytes, platelets and endothelial cells leading to the release of inflammatory mediators: eicosanoids, cytokines, chemokines, adhesion molecules, reactive free radicals, platelet activating factor (PAF) and NO'. In the circulation LPS may bind to plasme components such as high-density lipoproteins (HDL) or LPS binding protein (LBP). This complex interacts with a high affinity receptor CD14 expressed on leukocytes, monocytes and macrophages resulting in activation of these cells and inducing pathophysiological effects such as inflammation, septic shock and death. The consequences for the host of all these events are dependent on the extent of LPS exposure and the status of the host defense mechanisms.
16
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Sygnał świetlny UV w układach biologicznych (cz. 1). Detekcja promieniowania nadfioletowego w układzie fotoreceptorowym

100%
Bednarska K., Uniwersytet Łódzki K. B. O.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1999
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vol. 14
EN
Exposition of cells to UV radiation causes the different biological effects. In this paper the effects of low power UV radiation on photoreceptor system are presented.
17
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Ekspresja P-selektyny na powierzchni płytek krwi indukowana endotoksyną bakteryjną Proteus mirabilis

64%
Saluk-Juszczak J., Nowak P., Golański J., Wachowicz B., Kaca W., Uniwersytet Łódzki K. B. O., Akademia Medyczna w Łodzi I. K.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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2001
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vol. 15
EN
P-selectin is stored in the a granules of blood platelets. Following platelet activation by different agonists, P-selectin is expressed on the cell surface where it mediates adhesion primarily to leucocytes.The aim of the study was to evaluate the direct effect of Proteus mirabilis lipopolysaccharides on the P-selectin expression on the platelet surface measured by cytometric method. The obtained results showed that LPS in vitro induced the expression of P-selectin (CD62) on platelets. It indicates that endotoxin from Gram-negative bacteria can activate blood platelets.
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