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Role of endothelin-1 in cardiovascular regulation in haemorrhagic shock

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Jochem J., Josko J.
Postępy Higieny i Medycyny Doświadczalnej
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2000
|
vol. 54
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issue 6
835-843
EN
Endothelin-1 (ET-1), a 21-amino acid polypeptide, produced mainly in endothelial cells is the most potent mammalian vasoconstrictor peptide known. Haemorrhagic hypotension is accompanied by the increase in plasma ET-1 concentration. The significance of this effect, however, is not clear. This paper reviews the causes of the rise in ET-1 plasma concentration and the role of ET-1 in cardiovascular regulation in haemorrhagic shock.
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