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1

Calcium accumulation in synapses of the rat hippocampus after cerebral ischemia

100%
Gajkowska B., Mossakowski M. J.
Neuropatologia Polska
|
1992
|
vol. 30
|
issue 2
111-126
EN
The ultrastructural localization of calcium deposits in the synapses of rat hippocampus after 10 min global cerebral ischemia was evaluated. Oxalate-pyroantimonate technique was applied. After 24 hours of postischemic recirculation enhancement of intracellular (pre- and postsynaptic parts) and extracellular (synaptic clefts) calcium deposits was found in great proportion of synapses in CA1 sector. Abundant Ca-precipitates appeared specially in synaptics clefts and in the postsynaptic parts near synaptic densities. Increased calcium deposits in some changed mitochondria were also observed, The results presented in this paper suggest synaptic modulation of calcium homeostasis, disturbed after ischemic incident. Presence of Ca-precipitates in synaptic clefts and postsynaptic parts seems to be a sensitive indicator of increased calcium influx from the extracellular to the intracellular compartments.
2

Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy

71%
Kroh H., Taraszewska A., Ruzikowski E., Bidzinski J., Mossakowski M. J.
Neuropatologia Polska
|
1992
|
vol. 30
|
issue 2
133-146
EN
The study was performed on cerebral tissue resected during temporal lobectomy in 16 patients whose long-standing cryptogenic epilepsy did not submit to anticonvulsive drugs. Cases presenting definite etiological factors such as CNS trauma, infection or neoplasm were excluded. Neuropathological investigations disclosed microangiomas and focal vascular malformations in the meninges and tissue in 7 patients. Neuronal heterotopias in the white matter and of the white matter in the cortex were observed in 3 cases, Main cortical changes were: neuronal loss,chronic neuronal degeneration, perineuronal satellitosis, and GFAP-positive submeningeal gliosis, especially at the bottom of sulci, perivascular gliosis and laminar or diffuse gliosis. the changes in the hippocamus were most enhanced in the end-plate and in the sector H3 of the pyramidal layer. Astrocytic gliosis in the white matter presented distinct GFAP and S-100 immunostaining; the latter involved in some cases a wider area than the GFAP reaction. The above named changes are analysed with regard to the presumed epileptogenic factors and to the postepileptic damage.
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