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Distribution of HLA-C alleles determined by PCR-SSP in population of Low Silesia

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Prussak M., Manczak M., Pochron B., Nowak I., Kusnierczyk P.

Archivum Immunologiae et Therapiae Experimentalis

2003

vol. 51

issue 2

127-130

We typed 100 unrelated healthy Poles from Low Silesia region for HLA-C using low resolution PCR-SSP and compared observed allele frequencies with data published for other human populations. Poles appeared to be most similar to Germans and Englishmen, and were more distant from French, Catalans and Basques and dissimilar to non-Caucasoids from Equatorial Guinea and Japan. It would be interesting to HLA-C-type other Slavian and non-Slavian people from Middle and Eastern Europe for comparison.

Effect of IFN-on expression of HLA in bare-lymphocyte syndrome-like cell line HAJ

100%

Nowak I., Pochron B., Kozlowska A., Dubis J., Kusnierczyk P.

Archivum Immunologiae et Therapiae Experimentalis

2001

vol. 49

issue 6

453-

We compared HLA antigen expression on new B-lymphoblastoid cell line (B-LCL) HAJ with that on B-LCLs expressing normal HLA levels as well as on B-LCLs derived from bare lymphocyte syndrome (BLS) patients and in vitro mutated B-LCLs of BLS-like phenotype. HAJ cells had no expression of HLA class II and low expression of class I antigens similarly to some of BLS B-LCLs, although HAJ cell line was derived from lymphocytes of HLA class I- and class II-normally expressing donor. HAJ cells displayed B lymphocyte markers, surface immunoglobulin and CD19. Culture of HAJ cells in the presence of interferon gamma resulted in HLA class I antigen upregulation, but did not restore class II expression. The cell line HAJ may prove useful for studies on factors influencing HLA class I cell surface expression.

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2 Archivum Immunologiae et Therapiae Experimentalis

1 2003

1 2001

2 Kusnierczyk P.

2 Nowak I.

2 Pochron B.

1 Dubis J.

1 Kozlowska A.

1 Manczak M.

1 Prussak M.

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Distribution of HLA-C alleles determined by PCR-SSP in population of Low Silesia

Effect of IFN-on expression of HLA in bare-lymphocyte syndrome-like cell line HAJ