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Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones

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Vijayakumar R., Senbagam R., Rajarajan M., Balaji S., Manikandan V., Vanangamudi G., Thirunarayanan G.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2015

vol. 70

issue 2

Some novel substituted hydrazone derivatives of amino guanidine have been synthesized with different substituted benzaldehydes by condensation method. The synthesized hydrazones were characterized by their physical constants, UV, IR and NMR spectra. The spectral data have been correlated with Hammett substituent constants and Swain–Lupton parameters. From the result of statistical analysis, the effects of substituents on the spectral data have been predicted. The antimicrobial activities of these synthesized hydrazone compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized hydrazone compounds have shown significant activity.

Synthesis, spectral LFER and antimicrobial activities of some (E)-N׳-(1-(substituted phenyl)ethylidene)benzohydrazides

84%

Manikandan V., Balaji S., Senbagam R., Vijayakumar R., Rajarajan M., Vanangamudi G., Sundararajan R., Arulkumaran R., Thirunarayanan G.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2016

vol. 71

issue 2

About eleven substituted (E)-N׳-(1-(substituted phenyl) ethylidene) benzo- hydrazides have been synthesized. They are characterized by their analytical, ultraviolet, infrared and NMR spectral data. The antibacterial and fungal activities of these chalcones have been evaluated.

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2 Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

1 2016

1 2015

2 Balaji S.

2 Manikandan V.

2 Rajarajan M.

2 Senbagam R.

2 Thirunarayanan G.

2 Vanangamudi G.

2 Vijayakumar R.

1 Arulkumaran R.

1 Sundararajan R.

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Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones

Synthesis, spectral LFER and antimicrobial activities of some (E)-N׳-(1-(substituted phenyl)ethylidene)benzohydrazides