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Investigating Mechanisms of Radiation-Induced DNA Damage Using Low-Energy Photons

100%
Folkard M., Prise K.
Acta Physica Polonica A
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2006
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vol. 109
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issue 3
265-271
EN
Central to any mechanistic biophysical model of radiation damage to DNA is the relationship between the amount and distribution of energy deposited in the DNA helix and the subsequent production of DNA damage. It is now clear from a number of studies that the minimum energy required to produce bond breaks in DNA is significantly lower than might be expected. For example, some biophysical models have assumed that it takes several 10s of eV to produce a double-strand break in DNA. However, using low-energy photons, we have shown that energy depositions as low as 7 eV can induce double-strand break and that this is enhanced when the DNA is hydrated, showing that free radical damage is also important.
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Understanding Radiation Damage to Cells Using Microbeams

61%
Folkard M., Prise K., Shao C., Gilchrist S., Schettino G., Michette A., Vojnovic B.
Acta Physica Polonica A
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2006
|
vol. 109
|
issue 3
257-264
EN
Cellular micro-irradiation techniques provide unique experimental opportunities for understanding how ionizing radiation interacts with living cells and tissues. Using microbeams, it is possible to deliver precise doses of radiation to selected individual cells, or sub-cellular targets in vitro. This technique continues to be applied to the investigation of a number of phenomena currently of great interest to the radiobiological community. In particular, it is the study of so-called "non-targeted" effects (where cells are seen to respond indirectly to ionizing radiation) that are benefiting most from the use of microbeam approaches.
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