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EN
Hirudin is well known antithrombotic agent with potentially wide application in the clinical treatment of the diseases of circulatory system.In this review the autors discuss biochemical and functional properties of natural hirudins as well as recombinant forms of the protein.The genetic engineering approaches to hirudin expression as well as the methods and techniques of protein isolation and purification are discussed and summarized.We emphasize the most important advantages potentially originationg from the clinical use of hirudin as a specific thrombin inhibitor, and its potential role in clinical practice, particularly in regard to heparin preparations.
EN
Staphylokinase is a new promising therapeutic agent with an expanding clinical application in the treatment of vascular disease.In the present paper the autors discuss the biochemical and physiological properties of the recombinant protein.The methods and techniques of protein synthesis, isolation and purification, including the genetic engineering approaches are critically summarized.The emphasis is put onto the critical review of the experiments concerning the use of ataphylokinase in thrombotic models in experimental animals.Moreover, we discuss the potential role and advantages of staphylokinase over the other thrombolytic agents in the treatment of cardiovascular disease in humans.
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