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Treatment of deafness with the use of cochlear implants in children with severe heart defects

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Śmiechura-Gańczarczyk M., Waśniewska-Włodarczyk A., Konopka W.
Polski Przegląd Otorynolaryngologiczny
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2022
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vol. 11
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issue 4
1-6
EN
Aim: To assess the treatment of hearing loss in children with severe heart defects after cardiac surgeries in their early life. The evaluation included the preparation to surgery, the safety and effectiveness of cochlear implantation. Material and methods: It was a retrospective study. In our database, there are 7 children (age: 2.5–5.5) with congenital heart defect who had cardiac surgery. All of them were implanted with a Cochlear CI512 device. Late implantation was a result of a necessity to perform life-saving cardiac surgeries. The children are still under the observation of audiologists and speech therapists. Results: Assessment of the 4-frequency average of indicative free field audiometry shows that there is an increase in hearing ability within a given time period: without a sound processor (SP) the threshold of hearing had been 112.75 dB, with SP 3 months after surgery it was 67.5 dB, and 6 months after surgery it was 49 dB. After cochlear implantation, speech development of implanted children was faster than prior to cochlear implant (CI) surgery. Conclusion: Pre-operative planning reduces the intraoperative risk connected with cochlear implantation. Cochlear implantation is safe for children with heart defects if they are early diagnosed and treated.
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The impact of adipose fat tissue on the pathogenesis of crypto-glandular anal fistula

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Włodarczyk M., Włodarczyk J., Maryńczak K., Waśniewska-Włodarczyk A., Dziki Ł., Fichna J.
Polish Journal of Surgery
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2024
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vol. 96
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issue 5
12-17
EN
Indroduction: Cryptoglandular perianal fistula represents a prevalent benign anorectal condition, primarily addressed through surgical interventions, occasionally posing considerable therapeutic challenges. The associated decline in patient quality of life underscores the significance of effective management. However, the lack of a fully understood pathogenesis complicates the treatment approach. Recent research has proposed the involvement of adipose fat tissue in the inflammatory response and pathogenesis of cryptoglandular anal fistula. Aim: The study aims to characterize the role of adipose fat tissue in the pathogenesis of cryptoglandular anal fistula, with a specific focus on understanding the potential involvement of proinflammatory cytokines in the development of chronic inflammation. Materials and methods: This study involved the characterization of serum levels of inflammatory cytokines and adipose tissue hormones. A total of 35 samples from both simple and complex cryptoglandular perianal fistula cases were collected during surgical procedures. Results: Serum levels of leptin, resistin, IL-1β, and IL-8 were significantly elevated in patients operated on due to complex cryptoglandular perianal fistula when compared to patients with simple fistula. Adiponectin was significantly lowered in samples from complex perianal fistula in comparison to simple fistula. Conclusions: Complex perianal cryptoglandular fistula has a reduced level of anti-inflammatory adipokines i.e. adiponectin, and an increased level of proinflammatory resistin, leptin, IL-1β, and IL-8.
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