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PL
Roman Ossowski, od 1962 roku, jest uczestnikiem i świadkiem ogromnych zmian, które dokonywały się w teorii i praktyce rehabilitacji w drugiej połowie XX wieku i dwóch dekadach XXI wieku. Jego monografia stanowi istotny wkład do istniejących danych w tej ważnej dziedzinie, jaką jest psychologia rehabilitacji.
EN
Chemotherapy is the standard treatment for metastatic testicular cancers. The autologous hematopoietic stem cell transplantation is a salvage option for relapsed patients. The paper presents a case of a 20-year-old patient with stage IIIC non-seminoma treated with BEP chemotherapy and autologous transplantation of stem cells, which allowed to achieve durable remission.
PL
Uzależnienie od alkoholu prowadzi do zmian w aktywności mózgu i zaburzeń poznawczych, jednakże dane dotyczące wpływu spożywania niskich do umiarkowanych dawek alkoholu na funkcjonowanie poznawcze są niespójne. Celem badania była ocena wpływu 0,1-0,25 mg/dm3 stężenia alkoholu w wydychanym powietrzu na funkcje poznawcze, takie jak: uwaga, percepcja szybkości psychomotorycznej i funkcji wzrokowo-przestrzennych u 50 młodych nieuzależnionych od alkoholu dorosłych. Wyniki wykazały pogorszenie w zakresie koncentracji uwagi mierzonej aparatem krzyżowym po spożyciu badanej dawki alkoholu. Ujawniły one także występowanie efektu uczenia się w zakresie testów do badania uwagi i szybkości psychomotorycznej. Efekt ten był jednakże znacząco osłabiony u uczestników, którzy byli pod wpływem alkoholu w pierwszym badaniu. Uzyskane rezultaty wskazują, że badane stężenie alkoholu może mieć szkodliwy wpływ na koncentrację i zdolność do korzystania z wcześniejszych doświadczeń, które są kluczowe dla złożonych zachowań, takich jak prowadzenie pojazdów mechanicznych.
EN
Problem of the quality of life is a goal of scientific research for instance in psychology. Mostly it is considered in connection with evaluation of state of health, the level of cognitive and physical functionning and general well-being. The quality of life is considered in context of illness, disability and limits in everyday life.The goal of this study was comparision of selected factors: depression, cognitive functionning, age, sex and duration of disease, education with quality of life in Parkinson’s disease. Material and methods: 40 patients with Parkinson’s disease took part in the study. Following methods were used: Mini Mental State Examination_ MMSE, Beck Depression Inventory – BDI and Parkinson’s Disease Questionnaire – PDQ-39. Results: Obtained reults showed that somatic problems, motor ability, activity of daily living, cognitive functionning and emotional state are among the most affected areas of life. Support form relatives and communciation with the social environment were the least deteriorated. Significant correlation between depression and quality of life was observed. Conclusions: The results suggest that early recognition and proper treatment of depression may improve the quality of life and reduce some of the somatic disturbances.
EN
The article draws attention to the need to maintain oncological vigilance in the daily practice of a family doctor. Diagnosis and effective treatment of hypercalcemia and plasma cell myeloma are presented.
EN
The present study reports the case of a 40-year-old patient who presented SIADH syndrome due to anaplastic large T-cell lymphoma and antineoplastic drugs.
EN
The case describes an 86-year-old man with thrombosis of the deep dorsal vein and corpora cavernosa of the penis who developed symptoms 4 months before hospitalisation. An accurate imaging diagnostics supplemented with a biopsy of the corpus cavernosum confirmed the initial diagnosis. Moreover, an adenocarcinoma of the hepatic flexion of the colon with numerous metastatic lesions, including those to the crus of penis were found. Diagnostic and therapeutic difficulties were described and the results obtained were discussed in the context of available literature.
EN
A 63-year-old female patient was admitted to the hospital for an in-depth diagnosis of accidentally found pancreatic cystic lesion. The lesion was detected by computed tomography scan and magnetic resonance imaging of the abdomen and identified as potentially malignant mucinous cystic neoplasm (MCN). Endoscopic ultrasound-guided fine-needle aspiration biopsy with the analysis of the fluid from the cyst was performed as well and it confirmed the malignancy of the cystic lesion. The patient was qualified for surgery and the final diagnosis based on histopathological examination of the surgical material confirmed MCN with the accompanying invasive pancreatic adenocarcinoma.
PL
Celem pracy było określenie wartości prognostycznej markerów stanu zapalnego u pacjentów z potrójnie ujemnym rakiem piersi. Zebrano dane dotyczące 143 chorych i oceniono używając testu chi-kwadrat, testu Wilcoxon–Mann–Whitney oraz regresji Coxa. Stwierdzono związek między wysokim poziomem stosunku neutrofilów do limfocytów, płytek do limfocytów, wskaźnikiem ogólnoustrojowej reakcji immunologiczno-zapalnej a miejscowym stopniem zaawansowania: guz (T3/T4) (P=0.0001, P=0.0198, P=0.0001), dodatnie regionalne węzły chłonne (P=0.0014, P=0.0075, P=0.0206). Wielowymiarowa analiza wykazała, że choroba rozsiana, gorszy stan sprawności oraz wysoki stosunek neutrofilów do limfocytów (Hazard ratio: 4.48 [2.05-9.80], P=0.0002; 2.23 [1.24-4.03], P=0.0010; 2.23 [1.24-4.03], P=0.0075) stanowią negatywne czynniki prognostyczne. Wysoki stosunek neutrofilów do limfocytów oraz gorszy stan sprawności stanowią niezależne negatywne czynniki prognostyczne.
EN
The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.
EN
Abdominal surgery on patients with significant body malformation is often a challenge for an operative team. Particularly, when patient presents lesions suspected for malignancy but benign disease cannot be excluded. In the reported case the patient suffered from cerebral palsy and had extreme spinal distortion with significant displacement of internal organs. Solid renal mass was detected incidentally, but because of body deformation the biopsy to asses pathological status could not be performed. The decision to perform surgery was made and the patient underwent successful laparoscopic partial nephrectomy. Pathology examination of the specimen revealed renal cell carcinoma grade 2.
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