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1

ANALYSIS OF MODEL DRUG RELEASE KINETICS FROM COMPLEX MATRICES OF POLYLACTIDE-CHITOSAN

100%

Balcerzak J., Mucha M.

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vol. 15

117 - 126

EN

In the present paper the Authors analyse the experimental results of a model drug (ibuprofen) release approximated with three commonly used semi-empirical models: Korsmeyer-Peppas, first order kinetics and Gallagher-Corrigan equation. Drug carriers in the form of films composed of chitosan matrix and polylactide microparticles were produced by ultrasonic emulsification with solvent evaporation followed by film casting technique. Additionally, polylactide shield layers (5μm thick) were attached to both sides of obtained films by means of spray-coating process. A microscopic analysis confirmed the uniform distribution of polylactide microparticles (diameter: 1-2 μm) within chitosan films. Based on the of microscopic study, molecular drug dispersion within composite matrices was found. Fraction of ibuprofen released into medium of pH equal to 1.4 or 7.2 (GI tract) was measured by means of UV-VIS spectrophotometry. The finest approximation was obtained by fitting two-stage release model derived by K. M. Gallagher and O. I. Corrigan to the release data. Analysis of model parameters led to the conclusion that the increase of composite films thickness as well as weight fraction of PLA microparticles within films prolong drug release.

2

PREPARATION OF MICRO AND NANOSTRUCTURES OF CHITOSAN BY ULTRASONIC COALESCENCE OF W/O EMULSIONS

81%

Balcerzak J., Kucharska M., Gruchała B.

Progress on Chemistry and Application of Chitin and its Derivatives

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2013

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vol. 18

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issue 18

13-20

EN

In the paper, the preeliminary study of chitosan micro and nanospheres precipitation due to two reverse emulsions (W/O) coalescence is described. The composition conditions, which must be filled to obtain stable reverse emulsion is pointed out. Furthermore, the parameters of ultrasonic emulsification and coalescence technique are presented and finally, morphological study of obtained micro and nanospheres are discussed.

3

SALICYLIC ACID RELEASE FROM CHITOSAN PELLETS COATED WITH POLYLACTIDE

81%

Mucha M., Balcerzak J., Filipiak A.

Progress on Chemistry and Application of Chitin and its Derivatives

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2011

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vol. 16

79 - 88

EN

The aim of the study was to prepare a bi-polymer drug carrier composed of chitosan pellets (CS) coated with polylactide shell (PLA) providing prolonged model drug – salicylic acid (SA) release into phosphate buffer of pH = 7.2. Pellets were obtained through a coacervation followed by a freeze-drying process. In a terms of model drug loading, porous pellets were impregnated with a SA solution under vacuum. Afterwards, loaded and dried beads were coated with PLA films through their dipping in a PLA organic solution. FTIR spectroscopy was implemented to analyse the efectiveness of SA loading process. The UV-Vis spectrophotometry kinetic studies of a model drug release from PLA coated and non-coated pellets into phosphate buffer were conducted. Increasing time of CS pellets impregnation with SA solution resulted in decrease of salicylic acid release rate.This tendency was more evident for the SA release from pellets coated with an additional layer of PLA. Model drug release kinetic points were well approximated with first order kinetics model.

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3 Progress on Chemistry and Application of Chitin and its Derivatives

1 2013

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3 Balcerzak J.

2 Mucha M.

1 Filipiak A.

1 Gruchała B.

1 Kucharska M.

ANALYSIS OF MODEL DRUG RELEASE KINETICS FROM COMPLEX MATRICES OF POLYLACTIDE-CHITOSAN

PREPARATION OF MICRO AND NANOSTRUCTURES OF CHITOSAN BY ULTRASONIC COALESCENCE OF W/O EMULSIONS

SALICYLIC ACID RELEASE FROM CHITOSAN PELLETS COATED WITH POLYLACTIDE