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When small RNAs become smaller: emerging functions of snoRNAs and their derivatives

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Mleczko A., Bąkowska-Żywicka K.

Acta Biochimica Polonica

2016

vol. 63

issue 4

601-607

Small nucleolar RNAs (snoRNAs) are molecules located in the cell nucleolus and in Cajal bodies. Many scientific reports show that snoRNAs are not only responsible for modifications of other RNAs but also fulfill multiple other functions such as metabolic stress regulation or modulation of alternative splicing. Full-length snoRNAs as well as small RNAs derived from snoRNAs have been implied in human diseases such as cancer or Prader-Willi Syndrome. In this review we describe emerging, non-canonical roles of snoRNAs and their derivatives with the emphasis on their role in human diseases.

Ex-translational function of tRNAs and their fragments in cancer

81%

Mleczko A., Celichowski P., Bąkowska-Żywicka K.

Acta Biochimica Polonica

2014

vol. 61

issue 2

211-216

Transfer RNA (tRNA) molecules are most commonly known as the molecular amino acids carriers and also because of the role they play in a protein biosynthesis process. However, tRNA biology has revealed stupendous levels of many unexpected discoveries that put a new light on tRNA function in different processes besides translation, like apoptosis or cancer development. In recent years various species of RNAs have been found differentially expressed in different types of cancer. In this review we focus our attention on tRNAs as well as on tRNA-derived small RNAs ex-translational functions in human cells in oncogenesis and oncobiology.

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2 Acta Biochimica Polonica

1 2016

1 2014

2 Bąkowska-Żywicka K.

2 Mleczko A.

1 Celichowski P.

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When small RNAs become smaller: emerging functions of snoRNAs and their derivatives

Ex-translational function of tRNAs and their fragments in cancer