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The influence of beta-carotene, retinoids, RAR and RXR receptors on proliferation and neoplastic transformation of cells

100%

Staniaszek K., Gozdzicka-Jozefiak A.

Biotechnologia

2008

issue 3

28-45

Beta carotene is a member of a class of substances called carotenoids. Beta carotene, alpha carotene and beta cryptoxanthin can serve as dietary precursors of retinoids (RA, all-trans retinol or provitamin A). Biological effects of retinoids and expression of RA responsive gene are mediated by different receptors, namely RAR and RXR in homodimeric or heterodimeric form. Expression levels of the retinoic acid receptors are significantly different in neoplastic tissues compared with non-neoplastic tissues for many types of tumors.

Epithelial cell cultures as a model system to study the transepithelial transport

81%

Grajek W., Olejnik A., Staniaszek K.

Biotechnologia

2006

issue 2

148-165

Epithelial cell lines are commonly accepted model system to determine intestinal permeability and transepithelial transport. The application of Caco-2 human epithelial cell culture can be used to study bioavailability of drug and food compounds. This culture grows on porous membranes and forms a monolayer of well differentiated cells joined by intracellular tight junctions. This system provides selective barrier to study passive and active transport of different molecules. The Caco-2 cells posses some enzymes and transport systems similar to intestinal epithelium in vivo, however, these proteins are expressed to a lesser extent compared to normal enterocytes. In this paper, the advantages and limitations of Caco-2 model are discussed.

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2 Biotechnologia

1 2008

1 2006

2 Staniaszek K.

1 Gozdzicka-Jozefiak A.

1 Grajek W.

1 Olejnik A.

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The influence of beta-carotene, retinoids, RAR and RXR receptors on proliferation and neoplastic transformation of cells

Epithelial cell cultures as a model system to study the transepithelial transport