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The Serum Lipid Profile of Hypertensive Patients in Isiala Mbano, Imo State, Nigeria

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Uche E. M., Chinedu E. D., Berry I. C., Akubuo C. R.-M., Kelechi O. L.
World News of Natural Sciences
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2025
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vol. 63
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issue 2
93-101
EN
This research assessed the serum lipid profiles in patients with hypertension and explored their association with hypertension in Isiala Mbano, Imo State, Nigeria. A total of 127 participants, both male and female, aged 25 years and above, were recruited and divided into hypertensive (n = 80) and normotensive (n = 47) cohorts. Hypertension was identified based on the World Health Organization (WHO) guidelines after taking three consecutive blood pressure readings. Venous blood samples (5 mL) were collected in a sterile manner into plain tubes for biochemical evaluation. Serum concentrations of Total cholesterol (TC), Triglycerides (TG), High-density lipoprotein (HDL) cholesterol, and Low-density lipoprotein (LDL) cholesterol were measured using standardized enzymatic colorimetric techniques. TG exhibited a moderate positive correlation with both TC and HDL (p < 0.001). TC showed a strong positive correlation with HDL and LDL and a moderate positive correlation with TG (all p < 0.001). HDL presented a moderate positive correlation with TG and LDL (p < 0.001), while LDL demonstrated a moderate positive correlation with HDL and TG (p = 0.001). No noteworthy correlation was found between TG and LDL. The hypertensive individuals in this study displayed dyslipidaemic characteristics, with significant positive inter-correlations among different lipid fractions. It is recommended that routine lipid profile evaluations and the early treatment of dyslipidaemia be incorporated into hypertension management to diminish cardiovascular risk.
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