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Nietypowe bóle twarzy – neuralgia Sludera – leczenie miejscowe – przyżeganie zwoju skrzydłowo-podniebiennego fenolem – opis przypadków

100%

Olszewska-Ziąber A., Ziąber J., Rysz J.

Polish Journal of Otolaryngology

2007

vol. 61

issue 3

319-321

Aim. Chronic reccuring head and facial pain can be very difficult for successful treatment. Such a pain can be in some rare cases Sluder’s sphenopalatine ganglion neuralgia.The aim of the study was to obtain the pain relief by local treatment in patients with Sluder’s sphenopalatine ganglion neuralgia. Methods. We described three cases of Sluder’s neuralgia among all the seventeen patients with reccuring head and face pain that were seen in our department. In all these cases 4% Xylocaine was applied intranasally, into the region of shenopalatine ganglion, behind the posterior tip of the middle turbinate four times for ten minutes. According to Kern, the diagnosis of Sluder’s neuralgia was confirmed only in cases where local anesthetic block of the sphenopaltine ganglion was successful. It means the patients were pain-free for at least an hour after application of Xylocaine, so they were qualified for phenolization and 88% phenol was applied on the cotton carriers (number of the applications depended on the patient). Results. The total relief of pain of different duration was obtained in all the presented cases. Conclusion. The relief of pain obtained by intranasal phenolization of sphenopalatine ganglion in three patients shows it could be the effective treatment of Sluder’s neuralgia. The patients were totally free from the pain and accompanying symptoms like nasal obstruction, rhinorrhea, epiphora or conjunctivitis. The relief period was different but the patients were satisfied with the effectiveness and simplicity of the treatment. They did not need to take the additional medications for months and were able to continue work.

Enhanced inhibition of nasal epithelial cell repair by innate stimulation in patients with allergic rhinitis

76%

Lewandowska-Polak A., Brauncajs M., Jarzębska M., Olszewska-Ziąber A., Makowska J., Kowalski M. L.

issue 1

18-23

Introduction. Impaired repair of airway epithelium may lead to persistence of inflammation and remodelling. Regeneration of injured epithelium is a complex phenomenon and the role of toll-like receptors (TLRs) and respiratory virus products in this process have not been established. Aim of the study. In this study we aimed to test if wound repair in nasal epithelial cells is modulated by microbial products and if this process was different in patients with allergic rhinitis and in healthy subjects. Materials and methods. Injured human nasal epithelial cells (hNECs) monolayers were incubated with the toll-like receptors agonists: poly (I:C) and lipopolisacharide (LPS); allergen Der p1, and supernatants from virus-infected epithelial cells. Regeneration of injured epithelium was assessed by measuring changes in the area of epithelial damage. Results. Addition of either poly (I:C) or LPS induced a dose dependant inhibition of wound repair in hNECs monolayers. Supernatants from RV1b-infected cells decreased epithelial cell regeneration after mechanical injury only in allergic patients. At baseline conditions the dynamics of epithelial repair was similar in allergic and non-allergic epithelium. However, inhibitory effects of innate stimuli on epithelial repair was stronger in patients with allergic rhinitis as compared to healthy individuals. Conclusions. This study showed that microbial products may affect regeneration of the nasal epithelium, and allergic patients are more susceptible to suppression of epithelial regeneration.

Wprowadzenie. Upośledzenie regeneracji nabłonka dróg oddechowych może prowadzić do utrzymywania się stanu zapalnego i zapoczątkowywać przebudowę błony śluzowej. Proces regeneracji jest zjawiskiem złożonym i nie w pełni poznanym, a rola stymulacji receptorów toll-podobnych (TLR) w tym procesie nie została określona. Cel pracy. Ocena wpływu produktów drobnoustrojów na regenerację nabłonka górnych dróg oddechowych i porównanie regeneracji u osób chorych na alergiczny nieżyt nosa i osób zdrowych. Materiał i metody. Komórki nabłonka nosa pobrane od osób chorych na alergiczny nieżyt nosa i zdrowych hodowano do zlewności, a następnie uszkadzano mechanicznie. Do uszkodzonych hodowli dodawano agonistów receptorów toll-podobnych: poli (I:C) lub lipopolisacharyd (LPS), supernatant z komórek nabłonkowych zakażonych rinowirusem lub alergen Der p1. Regenerację komórek oceniano poprzez powierzchnię uszkodzenia. Wyniki. Inkubacja uszkodzonych hodowli z poli (I:C) lub lipopolisacharydem powodowała hamowanie naprawy nabłonka. Dodanie nadsączu z hodowli zakażonych rinowirusem również hamowało regenerację u chorych na alergiczny nieżyt nosa. Silniejsze zahamowanie stwierdzono u osób chorych na alergiczny nieżyt nosa niż u osób zdrowych. Wniosek. Produkty drobnoustrojów wywierały efekt modulujący regenerację nabłonka nosa, a osoby atopowe były bardziej podatne na zahamowanie regeneracji nabłonka.

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1 Alergia Astma Immunologia - przegląd kliniczny

1 Polish Journal of Otolaryngology

1 2019

1 2007

2 Olszewska-Ziąber A.

1 Brauncajs M.

1 Jarzębska M.

1 Kowalski M. L.

1 Lewandowska-Polak A.

1 Makowska J.

1 Rysz J.

1 Ziąber J.

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Nietypowe bóle twarzy – neuralgia Sludera – leczenie miejscowe – przyżeganie zwoju skrzydłowo-podniebiennego fenolem – opis przypadków

Enhanced inhibition of nasal epithelial cell repair by innate stimulation in patients with allergic rhinitis