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1

Immunopathology of Grave's disease

100%
Baj Z., Ferenc T., Lewinski A.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
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issue 5
531-546
EN
The pathogenesis Graves' disease, an autoimmune disorder, is not fully understood. Immune disturbances, genetic predisposition and environmental factors, affecting thyroid gland, appear to play the main role in contribution and development of the disease. Autoreactive T lymphocyte infiltrates in the thyroid gland and/or in the retroorbital tissues and autoantibodies to TSH receptor detected in almost all of the patients, have been considered to be responsible for hyperthyroidism, ophtalmopathy, pretibial dermopathy and goiter. In this review, we describe some recent reports on the pathophysiological and immunological aspects of the thyroidal and extrathyroidal manifestations of the Graves' disease.
2

Effect of cardiopulmonary bypass on neutrophil activity in pediatric open-heart surgery

76%
Pasnik J., Siniewicz K., Moll J., Moll J. A., Baj Z., Sysa A., Zeman K.
Archivum Immunologiae et Therapiae Experimentalis
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2005
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vol. 53
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issue 3
272-277
EN
The nature of the participation of neutrophils in the post-cardiopulmonary bypass (CPB) inflammatory response is not very clear. The aim of our study was to investigate alterations in neutrophil phagocytic activity and adhesion molecule expression on these cells in children during and after CPB. Twenty-one children aged 6?33 months with congenital heart disease, scheduled for primary corrective surgery, were enrolled. The expressions of CD11b adhesion molecules and Fcg receptor on neutrophils and their phagocytic activity were evaluated. The studied markers were sequentially measured before, at the initiation of, and after CPB. During the course of the operation, CD11b molecule expression on neutrophils showed a slight elevation at the start of CPB (876.5104.8 mean fluorescence intensity, MFI, vs. 768.1178.2; p=0.0047), followed by a significant decrease to 689.01166.7 MFI after completion of the procedure. The expression of CD11b molecule on neutrophils measured at the end of CPB inversely correlated with the duration of CPB (r= ?0.68, p=0.00059). The expression of CD16 antigen dropped significantly at the start of CPB (1164.6307.3 MFI vs. 1327.4345.3 MFI; p=0.0007) and remained decreased until the end of CPB (814.0198.1 MFI). These findings suggest that the characteristics of the neutrophil response to cardiac surgery appear to depend on many factors. We demonstrated a link between the duration of CPB and adhesion molecule expression on neutrophils.
3

TNF-alpha priming effect on polymorphonuclear leukocyte reactive oxygen species generation and adhesion molecule expression in hemodialyzed patients

76%
Rysz J., Banach M., Stolarek R. A., Pasnik J., Cia?kowska-Rysz A., Markuszewski L., Baj Z.
Archivum Immunologiae et Therapiae Experimentalis
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2006
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vol. 54
|
issue 3
209-215
EN
Introduction: The study aimed to assess reactive oxygen species generation and the expressions of some surface antigens on polymorphonuclear leukocytes (PMNs) in patients on regular hemodialysis (HD) treatment. Materials and Methods: The respiratory burst of PMNs was determined with luminol-dependent chemiluminescence (CL) in resting cells and following N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol 12-myristate 13-acetate (PMA), or opsonized zymosan (OZ) stimulation and expressed in arbitrary CL units times assay-time (aUmin). The expressions of CD11b/CD18, CD10, and CD13 receptors were determined with flow cytometry. Results: Basal PMN CL was increased in HD patients to up to 1285129 aUmin compared with 89588 aUmin in healthy controls (p<0.05). The CL of unprimed PMNs increased after fMLP stimulation from 3085746 to 4529808 aUmin, and after OZ stimulation from 129451296 to 146781355 aUmin. PMA-stimulated CL of PMNs was similar to control values. The oxidative burst in PMNs from HD patients and healthy controls was similar in response to TNF-alpha alone. The CL of TNF- alpha-primed PMNs in HD patients was significantly lower than CL measured in healthy controls (p<0.05). The expressions of CD10 and CD13 metalloproteinase receptors were also increased (p<0.05). Although CD11b expression was significantly increased at rest and after fMLP stimulation, the expression of another beta-integrin heterodimer compound, CD18, was not increased. Conclusions: These results provide evidence that TNF- priming of PMNs is down-regulated in HD patients despite constitutive up-regulation of resting cytotoxicity and enhanced expression of adhesion and metalloproteinase receptors.
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