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CHARACTERISATION OF CHITOSAN/HYALURONIC ACID BLEND FILMS MODIFIED BY COLLAGEN

100%
Lewandowska K., Alina S., Grabska S., Michalska M.
Progress on Chemistry and Application of Chitin and its Derivatives
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2017
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vol. 22
125-134
EN
In the present study, thin films based on the blends of chitosan (Ch) and hyaluronic acid (HA) with and without collagen (Coll) were characterised using tensile tests, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). Ch/HA and Ch/HA/Coll polymer blends were prepared using the solvent evaporation technique. The interactions between polymer components in the binary and ternary blends were studied by FTIR analysis. Mechanical properties were studied and compared with those of simple polymer films. These results show that the addition of collagen into Ch/HA blends led to the increase of tensile strength and Young modulus. Moreover, it was found that the thermal stability of the Ch/HA binary blend significantly increased upon the addition of collagen.
2
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Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

88%
Michalska M., Pająk W., Kołodziejska J., Łazarenkow A., Nawrot-Modranka J.
Acta Biochimica Polonica
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2008
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vol. 55
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issue 3
613-617
EN
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
3
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The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

88%
Łazarenkow A., Michalska M., Mirowski M., Słomiak K., Nawrot-Modranka J.
Acta Biochimica Polonica
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2017
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vol. 64
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issue 3
585-590
EN
The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.
4
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The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line

76%
Łazarenkow A., Michalska M., Gorąca A., Mirowski M., Nawrot-Modranka J., Piechota-Polanczyk A.
Acta Biochimica Polonica
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2013
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vol. 60
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issue 2
259-262
EN
Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).
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