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A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets.

100%

Mužíková J., Novotná A., Bartoš M.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 2

355-365

Avicel HFE-102 is a co-processed dry binder containing 90 % microcrystalline cellulose and 10 % mannitol. This paper compares this co-processed dry binder and a physical mixture of related dry binders, microcrystalline cellulose (Avicel PH-102) and mannitol (Pearlitol 100SD) in the ratio of 9:1. Flow properties, compressibility, lubricant sensitivity, tensile strength, friablity and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel PH-102 alone. The flow properties of the co-processed dry binder Avicel HFE-102 alone and the physical mixture were comparable. Avicel HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity and tablet friability than the physical mixture of dry binders. Addition of lubricants exerted different effects on the disintegration of tablets. The co-processed excipient Avicel® HFE-102 is suitable for the use in orally dispersible tablets.

The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets

88%

Komersová A., Lochař V., Myslíková K., Mužíková J., Bartoš M.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 5

1223-1231

The aim of this study was to evaluate the use of co-processed dry binder MicroceLac®100 (lactose and microcrystalline cellulose in ratio 3:1) and Comprecel® 102 (pure microcrystalline cellulose) in formulations for the extended release of verapamil hydrochloride. Hydrophilic matrix tablets containing verapamil hydrochloride, hypromellose and dry binder were prepared by the direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents. Using scanning electron microscopy regular distribution of the active substance in the prepared tablets was confirmed. Release of verapamil hydrochloride from the prepared formulations was studied by the dissolution test method. The dissolution profiles were fitted to the first-order kinetic model, Higuchi diffusion model, Korsmeyer-Peppas and Weibull model and kinetic parameters as the first order release rate constant (k1), release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH) and parameters of Weibull model (b, λ) were determined. Based on results of non-linear regression analysis, the higher release rate constants were found for formulations containing co-processed dry binder MicroceLac®100 in comparison with formulations containing pure microcrystalline cellulose (Comprecel® 102). In addition, tablets swelling, erosion and disintegration during the dissolution test were monitored photographically.

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2 Acta Poloniae Pharmaceutica - Drug Research

1 2019

1 2018

2 Bartoš M.

2 Mužíková J.

1 Komersová A.

1 Lochař V.

1 Myslíková K.

1 Novotná A.

Search results

A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets.

The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets