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Mutant HIV-1 Protease Complexed with Tetrapeptide Inhibitor. Preliminary Report

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Skálová T., Hašek J., Dohnálek J., Petroková H., Buchtelová E.
Acta Physica Polonica A
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2002
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vol. 101
|
issue 5
659-663
EN
The paper presents preliminary description of structure determination of a mutant form of HIV-1 protease in a complex with a new pseudotetrapeptide inhibitor that retains its high affinity to this mutant enzyme (A71V, V82T, I84V). A highly efficient microdiffractometer installed for our experiment at the beamline ID14-1 enabled us to collect satisfactory data with crystal dimensions of about 40 micrometers.
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