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Intracellular potassium and chloride channels: An update.

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Dębska G., Kicińska A., Skalska J., Szewczyk A.

Acta Biochimica Polonica

2001

vol. 48

issue 1

137-144

Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targets for pharmacologically active compounds, e.g. mitochondrial potassium channels interact with potassium channel openers such as diazoxide. This review describes current observations concerning the properties and functional roles of intracellular potassium and chloride channels.

Mitochondrial potassium and chloride channels.

100%

Kicińska A., Dębska G., Kunz W., Szewczyk A.

Acta Biochimica Polonica

2000

vol. 47

issue 3

541-551

Channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They probably play an important role in mitochondrial events such as the formation of ΔpH and regulation of mitochondrial volume changes. Mitochondrial potassium and chloride channels could also be the targets for pharmacologically active compounds such as potassium channel openers and antidiabetic sulfonylureas. This review describes the properties, pharmacology, and current observations concerning the functional role of mitochondrial potassium and chloride channels.

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2 Acta Biochimica Polonica

1 2001

1 2000

2 Dębska G.

2 Kicińska A.

2 Szewczyk A.

1 Kunz W.

1 Skalska J.

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Intracellular potassium and chloride channels: An update.

Mitochondrial potassium and chloride channels.