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The value of magnetic resonance imaging in diagnosis and monitoring of treatment in multiple sclerosis

100%
Bekiesinska-Figatowska M., Walecki J., Stelmasiak Z.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 1
171-176
EN
We analysed MR examinations of 227 patients with multiple sclerosis. White matter hyperintensities in brain were found in 270 of them. The most frequently they were found in periventricular white matter (in 100% of cases), in subcortical localization (52.2%) and in the corpus collosum (44.4%). MR examination allows to estimate the activity of the disease on the basis of the presence of oedema around the plaques and their contrast enhancement with gadopentetate dimeglumine (Gd-DTPA). 17.8% of all cases showed the signs of the acute phase of MS. About one-third of all cases were accompanied by cortical brain atrophy (the most often seen in frontal lobes), subcortical brain atrophy was less frequent (one-sixth). In about two-third of all casese the corpus callosum atrophy was found. The analysis of follow-up MR examinations of 83 patients taking part in a double-blind placebo-controlled trial of new immunosupressive drug cladribine showed that patients from pacebo group were more compliant to any changes of plaques. Decrease of the plaques size was found mainly in women. No correlation between patients age and the plaques changes was established.
2
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Magnetic resonance imaging of brain abnormalities in patients with the Nijmegen breakage syndrome

76%
Bekiesinska-Figatowska M., Chrzanowska K. H., Jurkiewicz E., Wakulinska A., Rysiewski H., Gladkowska-Dura M., Walecki J.
Acta Neurobiologiae Experimentalis
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2004
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vol. 64
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issue 4
503-509
EN
The results of brain MRI are presented in 22 patients with documented Nijmegen breakage syndrome (NBS), aged from 1 and 9/12 to 20 years. T1-, PD or FLAIR and T2-weighted SE/TSE images in three planes were obtained. Twenty-one patients showed microcephaly. Decreased size of frontal lobes and narrow frontal horns of the lateral ventricles was observed in all cases. In 6 patients agenesis of the posterior part of the corpus callosum was found as well as colpocephaly and temporal horn dilatation. In 2 patients callosal hypoplasia was accompanied by other anomalies: abnormal cerebrospinal fluid spaces. Sinusitis was present in all patients as a result of primary immunodeficiency. As in ataxia teleangiectasia and other breakage syndromes, NBS patients show inherited malignancy susceptibility and hypersensitivity to X and g radiation. Because of that computed tomography is contraindicated in these patients and MRI should be the method of choice in diagnostic imaging.
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