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Acute idiopathic scrotal edema (AISE) is a rare, mild and self-limiting disease. The etiology and pathogenesis of this disease remain unclear. Diagnosing AISE requires the exclusion of other scrotal disorders. We report a 48-year-old Caucasian male patient admitted to the Department of Urology with an atypical course of AISE which persisted for 12 months, despite adequate conservative treatment. Accordingly, we propose a new term, chronic idiopathic scrotal edema (CISE), to describe an extremely rare cause of bilateral scrotal edema in adults.
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