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Botulinum toxin: structure, mode of action and therapeutic use

100%
Tatarkiewicz J.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
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vol. 48
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issue 5
505-520
EN
Structure, biological activity, mode and mechanism of action botulinum toxin as well as its therapeutic use is described.Botulinum toxin type A, one of the most potent biologic toxins, has been found to be of therapeutic value in the treatment of several neurologic and opthalmologic diseases.Its ability to produce chemical denervation of muscles makes it option for treatment of disorders in which traditional therapeutic procedure are of limited value (e.g. blepharospasm and other focal dystonias, strabismus, spasticity).
2
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Hydrogen in InP-Bonding and Passivation

63%
Baranowski J., Tatarkiewicz J.
Acta Physica Polonica A
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1991
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vol. 79
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issue 2-3
263-265
EN
A tight-binding total energy calculation shows that the possible hydrogen-indium bond in InP is long and weak whereas hydrogen-phosphorus bond is short and strong. The model explains the known experimental data, especially the lack of local vibrational modes of InH in InP implanted with protons and hydrogen passivation of acceptors but not donors in InP.
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