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1

Regulation of Ca2+ release from internal stores in cardiac and skeletal muscles.

100%

Wrzosek A.

Acta Biochimica Polonica

|

2000

|

vol. 47

|

issue 3

705-723

EN

It is widely accepted that Ca2+ is released from the sarcoplasmic reticulum by a specialized type of calcium channel, i.e., ryanodine receptor, by the process of Ca2+-induced Ca2+ release. This process is triggered mainly by dihydropyridine receptors, i.e., L-type (long lasting) calcium channels, directly or indirectly interacting with ryanodine receptor. In addition, multiple endogenous and exogenous compounds were found to modulate the activity of both types of calcium channels, ryanodine and dihydropyridine receptors. These compounds, by changing the Ca2+ transport activity of these channels, are able to influence intracellular Ca2+ homeostasis. As a result not only the overall Ca2+ concentration becomes affected but also spatial distribution of this ion in the cell. In cardiac and skeletal muscles the release of Ca2+ from internal stores is triggered by the same transport proteins, although by their specific isoforms. Concomitantly, heart and skeletal muscle specific regulatory mechanisms are different.

2

Endothelium as target for large-conductance calcium-activated potassium channel openers

100%

Wrzosek A.

Acta Biochimica Polonica

|

2009

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vol. 56

|

issue 3

393-404

EN

The endothelium is a highly active organ responsible for vasculatory tone and structure, angiogenesis, as well as hemodynamic, humoral, and inflammatory responses. The endothelium is constantly exposed to blood flow, sheer stress and tension. Endothelial cells are present as a vasculature in every tissue of the body and react to and control its microenvironment. A variety of ion channels are present in the plasma membranes of endothelial cells. These include potassium channels such as inwardly rectifying potassium (Kir) channels, voltage-dependent (Kv) channels, ATP-regulated potassium (KATP) channels and three types of calcium-activated potassium channels (KCa), the large (BKCa), intermediate (IKCa), and small (SKCa) -conductance potassium channels. Potassium current plays a critical role in action potentials in excitable cells, in setting the resting membrane potential, and in regulating neurotransmitter release. Mitochondrial isoforms of potassium channel contribute to the cytoprotection of endothelial cells. Prominent among potassium channels are families of calcium-activated potassium channels, and especially large-conductance calcium-activated potassium channels. The modulation of BKCa channels, which are voltage- and calcium-dependent, has been intensively studied. The BKCa channels show large expression dynamics in endothelial cells and tissue-specific expression of large numbers of alternatively spliced isoforms. In this review, a few examples of the modulatory mechanisms and physiological consequences of the expression of BKCa channels are discussed in relation to potential targets for pharmacological intervention.

3

Circular dichroism and fluorescence studies on interaction of calmodulin (CaM) with purified (Ca^2+-Mg^2+) ATPase of erythrocyte ghosts

51%

Wrzosek A., Famulski K. S., Pikuła S.

Acta Biochimica Polonica

|

1990

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vol. 37

|

issue 1

173-176

4

Annexin VI: An intracellular target for ATP

39%

Bandorowicz-Pikuła J., Danieluk M., Wrzosek A., Buś R., René Buchet, Pikuła S.

Acta Biochimica Polonica

|

1999

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vol. 46

|

issue 3

801-812

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Regulation of Ca2+ release from internal stores in cardiac and skeletal muscles.

Endothelium as target for large-conductance calcium-activated potassium channel openers

Circular dichroism and fluorescence studies on interaction of calmodulin (CaM) with purified (Ca^2+-Mg^2+) ATPase of erythrocyte ghosts

Annexin VI: An intracellular target for ATP