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  1. 1 World News of Natural Sciences

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  1. 1 2023

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  1. 1 Karangiya K.

  2. 1 Upadhyay J.

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Design, Synthesis, Characterization and Antimicrobial Screening of Newly Synthesized Isoxazole of Vanillin Analogues

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Karangiya K., Upadhyay J.
World News of Natural Sciences
|
2023
|
vol. 50
110-120
EN
Several 3-(Aryl)-5-[4-(2,4-dichloro-benzyloxy)-3-methoxy-phenyl]-isoxazole derivatives (1a-1h) have been synthesized by refluxing various 3-Methoxy-4-(2,4-dichlorophenylmethoxy) chalcones with hydroxylamine hydrochloride and catalytic amount of acetic acid results good to moderate yield. 3-Methoxy-4-(2,4-dichlorophenylmethoxy) chalcones were synthesized by constant stirring of 3-Methoxy-4-(2,4-dichlorophenylmethoxy)benzaldehyde with different substituted acetophenones. The analytical and physical data of all the synthesized compounds (1a-1h) were observed and reported. The structures of each newly synthesized isoxazole derivative have been characterized by various methods like Elemental analysis, Infrared spectroscopy, 1H-NMR spectroscopy, and Mass spectroscopy. Furthermore, each compound was screened for its in-vitro antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal towards fungi Aspergillus niger (A. niger) and Candida albicans (C. albicans) with the concentration of 40μg/ml and data was collected.
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