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  1. 1 Rak J.

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Mikrochimeryzm, płeć i choroby autoimmunologiczne

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Rak J.
Kosmos
|
2008
|
vol. 57
|
issue 1-2
19-28
EN
In general, autoimmune diseases affect women more often than men. Sex hormones and X chromosome genes are hypothesized to underlie this disproportion. Moreover, women are exposed to fetal cells trafficking from fetus to maternal circulation during pregnancy. These cells persisting in mother’s organism for years are defined as fetal microchimerism. Paralelly, fetus receives maternal cells which can persist into adult life as maternal microchimerism. Although mechanism of this phenomena is still not known, it is considered to be common among healthy people. Higher levels of microchimerism among women with scleroderma led to a hypothesis postulating its contribution to disease development. Furthermore, microchimerism was explored in other autoimmune diseases. More recent reports on capacity of microchimeric cells to differentiate and regenerate damaged tissue necessitate reconsideration of the first theories and give hope for new treatment strategies.
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