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Hepatoprotective activity of ethanolic peel extract of Saccharum officinarum L. against thioacetamide - induced liver injury in albino rats

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Amarachi C. D., Chukwugozie N. O., Blessing F.
World News of Natural Sciences
|
2026
|
vol. 64
11-20
EN
The liver plays an essential role in metabolism and detoxification, making it prone to damage by chemical agents. This study evaluated the hepatoprotective activity of ethanolic peel extract of Saccharum officinarum (SOPE) against thioacetamide (TAA) - induced liver injury in albino Wistar rats. Twenty-five rats were divided into five groups of five each. Two groups received 125 mg/kg and 250 mg/kg of SOPE, respectively, one received zinc lactate (200 mg/kg), one served as the normal control, and one as the TAA-only group. Treatments were administered orally for six days, followed by TAA (200 mg/kg, i.p.) on day seven. Biochemical markers (ALT, AST, ALP, total bilirubin, and albumin) and histopathological changes were assessed. SOPE significantly reduced (p < 0.001) ALT, AST, ALP, and total bilirubin levels, while increasing albumin in a dose-dependent manner. Histological results confirmed hepatoprotection, showing preserved hepatic structures in SOPE - treated rats compared with the TAA -only group. These findings suggest that Saccharum officinarum peel extract possesses potent hepatoprotective activity likely due to its antioxidant phytochemicals.
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