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1

Contribution of endothelial cells to immune processes.Influence of viral infection

100%
Zaczynska E.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
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vol. 48
|
issue 3
243-257
EN
Contribution of endothelial cells to normal immune processes (circulation of leukocytes, immune diapedesis, presentation of antigenes) as well as to pathology caused by viral diseases is described.Cytokine secretion and expression of adhesion molecules, particularly during viral infections are described.Permissiveness of endothelial cells to HIV infection is presented.Contrinution of herperviruses (CMV, HSV) to thrombosis and atherosclerosos is also considered.
2

Effect of cyclosporine A on the nonspecific, innate antiviral immunity of mice

63%
Zaczynska E., Blach-Olszewska Z.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
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vol. 49
|
issue 1 suppl.
53
EN
Different infections are the most common complication of immunosuppressive therapy. In this context, the effect of cyclosporine A (CsA) on the innate antiviral immunity of mice was studied. The presence of immunity was shown by infection of resident peritoneal cells (RPC) of BALB/c mice with herpes virus type 1 (HSV-1) and vesicular stomatitis virus (VSV). While the cells infected immediately after isolation were resistant to the viruses, the cells cultured for several days before infection lost immunity. The lack of activity to neutralize HSV-1 and VSV in the sera of the mice excluded a participation of specific antibodies in the resistance. To study the effect of CsA on innate immunity, BALB/ c mice were intraperitoneally (i. p.) injected with cyclosporine (20 or 100 mug/ mouse, twice a day) for three days. The other group of animals was injected in the same way with PBS only. Then the peritoneal cells were isolated and infected with VSV immediately after cell isolation. The kinetics of viral replication in the control and the CsA-treated groups was compared. While in the cells from the control group VSV did not multiply, in the cells from the CsA-treated mice the virus reached considerable titers. The cyclosporine effect on VSV replication was dose-dependent and statistically significant. We conclude that innate antiviral immunity was suppressed in the cyclosporine-treated mice and that this mechanism may be involved in the high susceptibility of patients to viral infections during immunosuppressive therapy.
3

Endothelium as target for virus infection

63%
Blach-Olszewska Z., Zaczynska E.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
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vol. 50
|
issue 3
233-243
EN
The review concerns the susceptibility of human endothelial cells to several viruses, especially CMV and HIV. Viral infections of endothelium in vivo develop usually in immuno-compromissed transplant recipients and in patients with AIDS. Endothelium of noninfected persons presents endogenous, nonspecific immunity against viruses. The constitutive production of cytokines with antiviral activities such as IFN, TNF and IL-6, seems to be responsible for the immunity of endothelium. The consequence of viral infections of endothelium (especially CMV) may be potentiation of allograft rejection and also development of artheriosclerosis. In the article the possible mechanisms and contribution of viruses to the processes are disscussed.
4
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Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering

39%
Kurzydłowski K. J., Ostrowska B., Jaroszewicz J., Zaczynska E., Tomaszewski W., Swieszkowski W.
Bulletin of the Polish Academy of Sciences: Technical Sciences
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2014
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issue 3
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