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P-Triazinylphosphonium chlorides as a new group of coupling reagents

100%

Kolesinska B., Mrozek A., Fraczyk J., Kaminski Z.

Open Chemistry

2013

vol. 11

issue 4

569-583

Tertiary phosphines in reaction with 2-chloro-4,6-dialkoxy-1,3,5-triazines gave unstable quaternary P-triazinylphosphonium chlorides, which readily decomposed with a departure of the alkyl group of the triazine ring substituent. Stable quaternary P-triazinylphosphonium chlorides were obtained only in reaction of 2-chloro-4,6-diphenoxy-1,3,5-triazine. Both, stable quaternary P-triazinylphosphonium chlorides as well unstable analogues prepared in situ activated carboxylic acid yielding “superactive” triazine esters, useful as highly efficient reagents in peptide bond synthesis. [...]

Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose

64%

Fraczyk J., Walczak M., Balcerzak W., Pokajewicz K., Wieczorek P., Młynarski W., Fendler W., Kaminski Z. J.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 4

1017-1029

A novel diagnostic method based on recognition of qualitative and quantitative composition of healthy and tumor tissue samples by library of molecular receptors was presented. Molecular receptors were formed by self-organization of N-lipidated peptides attached in the regular fashion via aminophenylamino-1,3,5-triazine linker to the surface of cellulose plate. For samples testing, the library was cloned into multiple, identical copies and for each experiment the new clone was used. The binding process was monitored by staining the discs with Brilliant Black and quantitative color measurement was performed in 256 grade gray scale. Substantial differences in the composition of healthy and tumor samples were observed in most cases. The highly individual chemical fingerprints were found to be reliant on the cancer type. For malignant papillary thyroid cancer statistical analysis identified two receptors most useful for diagnostic purposes.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 Open Chemistry

1 2018

1 2013

2 Fraczyk J.

1 Balcerzak W.

1 Fendler W.

1 Kaminski Z.

1 Kaminski Z. J.

1 Kolesinska B.

1 Mrozek A.

1 Młynarski W.

1 Pokajewicz K.

1 Walczak M.

1 Wieczorek P.

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P-Triazinylphosphonium chlorides as a new group of coupling reagents

Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose