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Contrast-enhanced Magnetic Resonance Imaging of lung cell cultures

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Bober Z., Pogoda K., Aebisher D., Tabarkiewcz J., Bartusik-Aebisher D.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 2
251-258
EN
Lung cancer is one of the most common types of cancer diagnosed, and the development of methods to image diseased lung tissue by MRI is of utmost importance. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) was used to noninvasively evaluate spin-spin relaxation time, T1, of lung cell cultures infused with various clinical gadolinium-based contrast media for imaging. In this study we used a clinical 1.5 Tesla scanner and the contrast agents: Omniscan, MultiHance, Gadovist and ProHance. A significant five-fold reduction of T1 relaxation time was obtained.
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