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Control of the cell cycle progression

100%

Grabarek J.

issue 3

61-71

There is no doubt that CDK/cyclin complexes play a central role in the regulation of the cell cycle. Many other components of the cell division cycle regulatory network have been identified recently. There is still much to be learned, however, about how these components cooperate to form this perfectly working mechanism. Many control points of the cell cycle regulatory mechanism are the same or similar across a wide range of eucaryotes. It is rather obvious that the cell division cycle is the most fundamental process for all living organisms. Still, there is no 'general' cell cycle. Individual regulatory mechanisms depend on the organism being studied and also on the developmental stage of cells within this organism.

The possible role of cell cycle stage in mammalian cloning

51%

Modlinski J. A., Grabarek J., Plusa B., Karasiewicz J.

Journal of Applied Genetics

2001

vol. 42

issue 2

153-176

Progress in mammalian cloning started from cloning embryos (of mice, rats, rabbits, sheep, goats, pigs, cattle and rhesus monkeys) and culminated in obtaining clones of sheep, cattle, pigs and mice from adult somatic cells. Knowing the relationship between the cell cycles of the recipient and the donor of cell nucleus in embryonic cloning by nuclear transfer one can adjust the phases of the cell cycle properly. Metaphase II recipients accept G1 (in most species) or G2 donors (in the mouse). Interphase recipients can harbour nuclei in all stages of cell cycle. Relatively little is known about somatic cloning. Two attitudes are applied: either the donor is in the G0 phase or the recipient is in a prolonged MII phase.

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1 Biotechnologia

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2 Grabarek J.

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1 Modlinski J. A.

1 Plusa B.

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Control of the cell cycle progression

The possible role of cell cycle stage in mammalian cloning