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Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease

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Liberski P. P., Sikorska B., Bratosiewicz-Wasik J., Walis A., Brown P., Brown D.

Acta Neurobiologiae Experimentalis

2003

vol. 63

issue 4

309-318

We report here on the exuberant glial reaction in the optic nerves affected by prion diseases. Optic nerves from CJD- and GSS-, and scrapie-infected mice and hamsters showed severe pathology. These lesions were qualitatively indistinguishable from each other but were more intense in the Fujisaki model than in the hamsters inoculated with Echigo-1. Exuberant cellular reaction comprised of macrophages containing numerous mitochondria, abundant rough endoplasmic reticulum, and secondary lysosomes filled with digested myelin debris, electron-dense material and occasionally, entire myelin-bound vacuoles were readily observed in both models. Macrophages actively digesting myelin fragments and containing lyre-like bodies and paracrystalline inclusions were frequently noted. Some macrophages extended long filopodia to form labyrinth-like structures, and within a few macrophages, concentric arrays of cisterns and channels sequestrated part of the cytoplasm. An analogous network of narrow cisterns was seen to surround whole segments of the myelinated fibers.

Gliomas: association of histology and molecular genetic analysis of chromosomes 1p, 10q, and 19q

84%

Gresner S. M., Rieske P., Wozniak K., Piaskowski S., Jaskolski D. J., Skowronski W., Sikorska B., Papierz W., Liberski P. P.

Acta Neurobiologiae Experimentalis

2007

vol. 67

issue 2

103-112

The aim of our study was to evaluate the frequencies of loss of heterozygosity (LOH) on chromosomes 1p, 10q, and 19q in gliomas and to correlate them with the histological diagnosis and with patient age and gender. We found deletions within chromosome 1p to be significantly associated with the histological subtype of glial tumor (P < 0.05); frequency of 1p deletions increased from astrocytoma (0%) through glioblastoma (31%) and oligoastrocytoma (57%) to oligodendroglioma (63%). In patients with 1p LOH, the odds for having astrocytoma or glioblastoma were approximately 10-fold and 4-fold lower, respectively, than oligodendroglioma. The odds for having oligoastrocytoma were similar to oligodendroglioma (OR = 1.3). The frequency of 10q LOH in patients with glioblastoma was significantly higher than in patients with oligodendroglioma (89% vs. 36%; P < 0.005). In patients with oligodendroglioma, most cases with LOH on chromosome 1p also had LOH 19q (90%), one case of 1p LOH also had a deletion on 10q. Statistical analyses revealed a significant association between deletions on 1p and 19q (P < 0.05). Our data provide evidence that use of molecular genetic analyses of chromosomes 1p, 19q, and 10q might improve the diagnosis of gliomas.

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2 Acta Neurobiologiae Experimentalis

1 2007

1 2003

2 Liberski P. P.

2 Sikorska B.

1 Bratosiewicz-Wasik J.

1 Brown D.

1 Brown P.

1 Gresner S. M.

1 Jaskolski D. J.

1 Papierz W.

1 Piaskowski S.

1 Rieske P.

1 Skowronski W.

1 Walis A.

1 Wozniak K.

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Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease

Gliomas: association of histology and molecular genetic analysis of chromosomes 1p, 10q, and 19q