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MicroRNA and Immune Response to Viral, Bacterial and Fungal Infections

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Agosile O. O., Benson U., Oduwe U., Okei N. C., Fajobi S. J., Akachukwu S. O., Oyetayo B. O., Faniyi A. J., Njoku P. C., Olagunju A. S.

World News of Natural Sciences

2022

vol. 44

24-42

Several kinds of microRNA have been studied as prospective biomarkers in the pursuit of better diagnostics tests for infectious diseases. miRNA which is processed mostly from introns plays a significant role in gene expression involving cell differentiation, proliferation, apoptosis, metabolism, and immune response. Many miRNA mimics or inhibitors are in their clinical phases and advancement in RNA interference will make miRNA become effective tools in the treatment of human infectious diseases. miRNA has been discovered to be largely involved in viral gene regulation as well as the change of host cellular genes during viral infections. The role of miRNA in most bacterial infections has not been thoroughly explored compared to viral infections. Recent studies have highlighted the vital role of host immunity against bacterial infections. miRNA that is sequenced due to fungal infections bear a close similarity to those produced in response to allergy or inflammation. Host-derived miRNA plays a vital role in immune regulation; inflammatory responses may be enhanced or inhibited by its upregulation or downregulation. Here, we outlined the involvement of microRNA in viral, fungal, and bacterial infections and the immune response associated. Further studies on these, will provide advanced diagnostic and treatment protocols for infectious diseases.

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1 World News of Natural Sciences

1 2022

1 Agosile O. O.

1 Akachukwu S. O.

1 Benson U.

1 Fajobi S. J.

1 Faniyi A. J.

1 Njoku P. C.

1 Oduwe U.

1 Okei N. C.

1 Olagunju A. S.

1 Oyetayo B. O.

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MicroRNA and Immune Response to Viral, Bacterial and Fungal Infections