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Rola eksemestanu w leczeniu raka piersi

100%
Wójcik E.
|
|
vol. 2
|
issue 4
264-268
EN
Hormonotherapy is one of the most important therapeutic options in the breast cancer treatment, either locally advanced or metastatic. Tamoxifen has been standard of care for many years, however new clinical trials results indicates aromatase inhibitors as a valuable alternative for postmenopausal patients. Exemestane is a steroid aromatase inhibitor with effectiveness proven in clinical trials discussed in this article.
PL
Leczenie hormonalne jest jedną z podstawowych opcji terapeutycznych w leczeniu raka piersi, zarówno miejscowo zaawansowanego, jak i przerzutowego. Standardem od wielu lat pozostaje tamoksyfen, jednak wyniki nowych badań klinicznych wskazują na inhibitory aromatazy jako na wartościową alternatywę w terapii pacjentek po menopauzie. Eksemestan jest steroidowym inhibitorem aromatazy, którego skuteczność została udowodniona na podstawie wyników badań omówionych w poniższym artykule.
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Efficacy and safety of non-pegylated liposomal doxorubicin in metastatic breast cancer therapy

51%
Wójcik E., Kufel-Grabowska J., Gierba-Tomczyk J.
OncoReview
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2017
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vol. 7
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issue 4
162-167
EN
Breast cancer is the most frequently diagnosed female cancer in Poland (over 17,500 women). Anthracyclines have become one of the most important drugs in breast cancer systemic treatment. In the treatment of metastatic disease combination chemotherapy with doxorubicin provides the objective response rate of 60–85%, and the median time of progression-free survival is about 12 months. Non-pegylated liposomal doxorubicin (NPLD) in combination with cyclophosphamide is associated with a lower risk of cardiotoxicity, higher efficacy and more favourable toxicity profile as compared with conventional anthracycline regimes. Two cases of females patients treated with NPLD described in this article demonstrate the importance of the choice of chemotherapy, professional monitoring, early detection and treatment of adverse effects. Non-pegylated liposomal doxorubicin ordained in systemic treatment of stage IV breast cancer prolongs survival and enhances the quality of life. It is a reasonable option for palliative therapy.
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