Search results

Sort By:

Limit search:

New, engineered polyketide compounds synthesized by actinomycetes

100%

Kuczek K.

Biotechnologia

2002

issue 4

130-141

Polyketides constitute a structurally and functionally diverse group of secondary metabolites produced by bacteria, fungi and plants. Macrocyclic polyketides are produced principally by actinomycetes using modular polyketide synthases which are giant multienzymes. These enzymes are potentially valuable for the biosynthesis of novel compounds. Engineered, hybrid polyketide synthases catalyse the formation of simple statin analogues, macrolactone ring analogues, and biologically active glycosylated compounds.

Bacterial small signaling molecules

63%

Pawlik K., Kuczek K.

Biotechnologia

2002

issue 4

115-120

Many bacterial species use small chemical molecules as signaling factors. Signal molecules are released into the environment and once a threshold concentration level has been achieved, they trigger a response in the target cells. This system of cell-cell signaling, termed as ?quorum sensing?, plays an important role in the coordination of the growth and other processes in bacterial populations. Two types of signaling molecules have been identified: (1) short peptides, common to Gram-positive bacteria and (2) carboxy-acid derivatives commonly utilised by Gram-negative bacteria. Bacteria of the genus Streptomyces utilize butyrolactones as signaling molecules and thus form a distinct group among Gram-positives. This review focuses on two model regulatory systems based on carboxy-acid derivatives: the regulation of bioluminescence in Vibrio fisheri and the regulation of streptomycin biosynthesis in Streptomyces griseus.

Refine search results

2 Biotechnologia

2 2002

2 Kuczek K.

1 Pawlik K.

Search results

New, engineered polyketide compounds synthesized by actinomycetes

Bacterial small signaling molecules