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Introduction: Recurrent respiratory papillomatosis is a rare disease with chronic and unpredictable course. The disease is an outcome of the HPV infection and it is characterized by the exophytic papillomas in the respiratory tract. Patients with RRP present a number of symptoms, from which the most dominant ones are hoarseness and dyspnoea. Treatment is mostly based on surgical procedures as well as adjuvant therapies. Case report: We present a case report of a 26-year old female patient with recurrent respiratory papillomatosis and comorbid recurrent esophageal strictures of unknown etiology. Discussion: RRP is a disease with both periodic intensifications of the symptoms and remissions. The course of the illness can be mild or aggressive. Patients with papillomatosis undergo numerous surgical procedures in the respiratory tract, which predisposes them to scars and adhesions in this area together with voice impairments and dysphagia. Conclusions: RRP is a relatively rate disease associated with many complications of survival treatment. Currently, due to the lack of effective causal treatment methods, patients are exposed to side effects of surgical procedures, hence it is important to continue activities aimed at obtaining standardized therapies that will improve the quality of life of patients with RRP.
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